Comparative Study between Letrozole versus Clomiphene Citrate in Treatment of Polycystic Ovaries (PCO) | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2025, Issue 1, January 2025 | ||||
| DOI: 10.58675/2682-339X.2875 | ||||
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| Authors | ||||
| Shaimaa Abdellatif; Ghada Soror; Shaimaa ELshaarawy | ||||
| Obstetrics and Gynecology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Polycystic Ovary Syndrome (PCOS) is probably the most common reason that influences females of childbearing age and regularly prompts barrenness. Aim: To compare Letrozole versus Clomiphene citrate in the treatment of Polycystic ovaries (PCOS). Patients and methods: This prospective clinical trial, involved 60 cases complaining of primary infertility diagnosed as PCOS and were selected from the Gynecology and Obstetrics clinics of Alzahraa University Hospital throughout the duration from January 2023 to August 2023. Results: Regarding endometrial thickness, in the Clomiphene citrate group, the mean endometrial thickness was 7.70±1.49 20% have 1 follicle not less than 18 mm on HCG administration day, 36.7% have 2 follicles, 26.7% have 3 follicles, 16.7% have 4 follicles. In Letrozole, the mean endometrial thickness was 9.37±7.14; 30% had 1 follicle not less than 18 mm on HCG administration day, 43.3% had 2 follicles, 26.7% had 3 follicles, and none had 4 follicles. There is a statistically insignificant distinction among the 2 groups regarding the number of follicles not less than 18 mm on HCG administration day. There is statistically significantly greater endometrial thickness in the Letrozole than in the Clomiphene citrate group. Regarding ovulation, the Letrozole group has a statistically significantly greater ovulation rate than the Clomiphene citrate group (83.3% vs 60%). Regarding pregnancy outcome, there was a statistically significant higher pregnancy rate in Letrozole than in the Clomiphene citrate group (33.3% vs 10%). Conclusion: The study compared Letrozole and Clomiphene citrate for treating polycystic ovaries, finding Letrozole significantly higher in ovulation, pregnancy rates, and endometrial thickness. | ||||
| Keywords | ||||
| Clomiphene citrate; PCOs; Letrozole | ||||
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