Clinical Significance of Red Distribution Width to Platelet Ratio in Evaluation of Hepatic Fibrosis in Metabolic Dysfunction Associated Fatty Liver Disease
Ibrahem, A., Al Dahshan, M., Abdel Baki, A., Eliwa, A., Masamer, H. (2645). Clinical Significance of Red Distribution Width to Platelet Ratio in Evaluation of Hepatic Fibrosis in Metabolic Dysfunction Associated Fatty Liver Disease. EKB Journal Management System, 2024(7), -. doi: 10.58675/2682-339X.2487
Atef Ibrahem; Magdy Al Dahshan; Amin Abdel Baki; Ahmed Eliwa; Hossam Aldein Masamer. "Clinical Significance of Red Distribution Width to Platelet Ratio in Evaluation of Hepatic Fibrosis in Metabolic Dysfunction Associated Fatty Liver Disease". EKB Journal Management System, 2024, 7, 2645, -. doi: 10.58675/2682-339X.2487
Ibrahem, A., Al Dahshan, M., Abdel Baki, A., Eliwa, A., Masamer, H. (2645). 'Clinical Significance of Red Distribution Width to Platelet Ratio in Evaluation of Hepatic Fibrosis in Metabolic Dysfunction Associated Fatty Liver Disease', EKB Journal Management System, 2024(7), pp. -. doi: 10.58675/2682-339X.2487
Ibrahem, A., Al Dahshan, M., Abdel Baki, A., Eliwa, A., Masamer, H. Clinical Significance of Red Distribution Width to Platelet Ratio in Evaluation of Hepatic Fibrosis in Metabolic Dysfunction Associated Fatty Liver Disease. EKB Journal Management System, 2645; 2024(7): -. doi: 10.58675/2682-339X.2487

Clinical Significance of Red Distribution Width to Platelet Ratio in Evaluation of Hepatic Fibrosis in Metabolic Dysfunction Associated Fatty Liver Disease

Al-Azhar International Medical Journal
Volume 2024, Issue 7, July 2024
DOI: 10.58675/2682-339X.2487
Authors
Atef Ibrahem1; Magdy Al Dahshan1; Amin Abdel Baki2; Ahmed Eliwa1; Hossam Aldein Masamer1
1Internal Medicine, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
2Gastroentrology and Hepatology, National Hepatology and Tropical Medicine Research Institute, Al-Azhar University, Cairo, Egypt
Abstract
Background: In 2020, the abbreviation "metabolic dysfunction-associated fatty liver diseases" (MAFLD) was employed to denote hepatic steatosis associated with systemic metabolic dysfunction. Aim and objectives: To evaluate the diagnostic and clinical use of the width of red cell distribution to platelet ratio as a noninvasive surrogate marker for liver stiffness in fatty liver diseases linked to metabolic dysfunction. Patients and methods: The current cross-sectional study was carried out on 100 MAFLD patients presented in the MAFLD outpatients' clinic, National Hepatology and Tropical Medicine Research Institute (NHTMRI) incorporation with El-Hussein University hospital-internal medicine department from March to August 2023. Results: The highest mean value of Red cell distribution width to platelet ratio (RPR) was higher in Fibrosis F4 (0.107±0.016), followed by Fibrosis F3 (0.098±0.013), then Fibrosis F2 (0.070±0.025), with the most negligible value recorded in F1 (0.044±0.012). RPR can be a noninvasive diagnosis indicator for predicting extensive fibrosis in patients with NAFLD. Conclusion: RPR is a straightforward and readily accessible measure for estimating the severity of MAFLD disease. When predicting MAFLD, the RPR index outperforms FAST, FIB-4, and APRI due to its greater AUC. In patients with MAFLD, RPR can be employed as a noninvasive diagnosis marker to forecast severe fibrosis.
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