Fecal Calprotectin as a Disease Activity and Prognostic Marker in Ulcerative Colitis | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2023, Issue 1, January 2023 | ||||
| DOI: 10.58675/2682-339X.1910 | ||||
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| Authors | ||||
| Mohamed Abdelrashed AbdelKhalik; Mohamed Ghareeb Mohamed; Amr Ahmed Rezk; Ahmed Elsherbiny Ibrahim Gomaa | ||||
| Gastroenterology, Hepatology and infectious diseases department, Faculty of Medicin, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Ulcerative Colitis (UC) is identified through endoscopy and biopsies. Endoscopy assesses a disease's severity. Calprotectin is a 24 kDa dimer of S100A8 and S100A9 calcium-binding proteins. Inflammatory bowel illnesses, celiac disease, and viral colitis elevate calprotectin levels in faeces. Aim: To examine the fecal calprotectin (FC) level in UC as a predictor of disease activity and prognosis as well as its correlation with other blood inflammatory markers. Subject and Methods: This cohort prospective study involved 150 cases who were be subjected to colonoscopy at Al-Azhar university hospitals endoscopic units. Patients were equally classified after colonoscopic examination into three groups: Group I: Consist of 50 patients with free colonoscopic examination. Group II:50 patients confirmedly diagnosed as UC after histopathological examination and Group III: 50 patients with colonoscopic disease rather than UC. Further Subgrouping of Group II: Group II (A): 50 patients confirmedly diagnosed as UC after histo-pathological examination before treatment. Group II (B): 50 patients confirmedly diagnosed as UC after histopathological examination after 3 months of specific treatment. Results: Group II had considerably more FC than group III, while FC was significantly lowest in group I than the other two groups. In group II, there is a significant positive correlation among FC with C reactive protein (CRP), erythrocyte sedimentation rate (ESR) & total leukocyte count (TLC). Meanwhile, there is a significant positive correlation among FC with CRP and ESR in group III. FC yielded significance at cutoff level of 184 µg/g with AUC of 0.845 with 87.5% sensitivity & 76.8% specificity. Conclusion: FC is considered a quick, reasonably priced, noninvasive diagnostic marker for UC disease activity and prognosis with high accuracy, sensitivity, and specificity. FC levels is reliable indicator of UC severity due to their correlation with other markers (ESR, CRP, and TLC). | ||||
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