Correlation of Acetylcholinesterase activity and bone biochemical markers in premature and full-term neonates | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2023, Issue 6, June 2023 | ||||
| DOI: 10.58675/2682-339X.1844 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Khaled Mohammed Elsayed1; Abd Elaziz Abd Elrahman Alnokaly1; Mohammed Abd El-malik Hassan2; Mabrouk Mahmoud Abo elenin1 | ||||
| 1Department of Medical Biochemistry, Faulty of Medicine, Al-Azhar University Cairo, Egypt. | ||||
| 2Department of Pediatrics, Faulty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Prematurity lowers body weight and bone mineral density in nearly 30% of preterm newborns. Premature newborns are not screened for metabolic bone disease, hence bone biochemical markers should be investigated. Acetylcholinesterase mediates bone remodeling in recent investigations. Bone biochemical indicators and acetylcholinesterase (AChE) levels in preterm newborns may be linked. Objective: The aim of our study is to evaluate the probable correlation of AChE levels with multiple bone biomarkers in full-term and premature neonates. Subjects and Methods: This study was designed as a case control study. We examined 80 newborns (40 preterm with gestational age less than 37 weeks, 40 full-term). Gender, gestational week, and weight were recorded. ALP, Ca, P, Mg, PTH, and 25-hydroxycholecalciferol were directly measured in serum. We also measured the AChE level. Results: Premature neonates had reduced Ca, P, and AChE levels but greater ALP and PTH. Gestational age increases body weight, Ca, and AChE levels. Gestational age correlated negatively with ALP and PTH. Conclusion: The results of the current study revealed that there was a gestational age-related increase in AChE level. There were significant relationships between AChE levels with P, Ca, PTH, 25OHD and ALP in preterm and full-term groups. | ||||
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