Assessment of Iodine status and thyroid Autoimmunity during pregnancy | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2024, Issue 12, December 2024 | ||||
| DOI: 10.58675/2682-339X.2818 | ||||
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| Authors | ||||
| Gamal Badr1; Mahmoud Abdelraouf1; Abdelsalam Abdelsalam2; Ahmed Khodier1 | ||||
| 1Internal Medicine, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt | ||||
| 2Clinical Pathology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Among the many different types of thyroid disorders that fall under the umbrella term "autoimmune thyroid diseases," the most common of which are Graves' disease (GD) and chronic autoimmune thyroiditis (HT). Thyroid hormone production requires iodine. It is still not known if iodine causes thyroid autoimmunity. Aim and objectives: To learn about anti-TPO levels and urine iodine levels in pregnant women. Subjects and methods: One hundred pregnant women and fifty non-pregnant women were part of this prospective cross-sectional study. Tests for serum iodine, anti-TPO, free thyroid hormone, and total serum thyroid hormone were performed on both groups. Two groups of patients were created from the pool of AL-HUSSIEN Hospital attendees: There were 100 pregnant women in Group 1 and 50 non-pregnant women in Group 2. Results: This study showed a significant difference in urinary iodine levels between the two studied groups. Iodine deficiency was more prevalent in the pregnant group than in the non-pregnant group. Regarding serum anti-TPO, there was no statistically significant difference between the two studied groups. Conclusion: Sera anti-TPO levels were not statistically different across groups. Urinary iodine insufficiency was higher in pregnant women than in non-pregnant women. In pregnant women, urinary iodine levels negatively correlate with TSH, while in non-pregnant women, they do not. Both pregnant and non-pregnant groups had a weak negative connection between urine iodine and TPOAbs. The two factors may be inversely related, with lower urine iodine levels implying higher TPOAbs levels. | ||||
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