Role of Serum Bicarbonate and Lactate as a Predictor of Mortality in Critically Ill Patient with Sepsis
Ali, A., Qutb, S., Abdelaziz, S., Abd El Fatah, N. (2646). Role of Serum Bicarbonate and Lactate as a Predictor of Mortality in Critically Ill Patient with Sepsis. EKB Journal Management System, 2024(12), -. doi: 10.58675/2682-339X.2810
Amani Ali; Seham Qutb; Sara Abdelaziz; Nada Abd El Fatah. "Role of Serum Bicarbonate and Lactate as a Predictor of Mortality in Critically Ill Patient with Sepsis". EKB Journal Management System, 2024, 12, 2646, -. doi: 10.58675/2682-339X.2810
Ali, A., Qutb, S., Abdelaziz, S., Abd El Fatah, N. (2646). 'Role of Serum Bicarbonate and Lactate as a Predictor of Mortality in Critically Ill Patient with Sepsis', EKB Journal Management System, 2024(12), pp. -. doi: 10.58675/2682-339X.2810
Ali, A., Qutb, S., Abdelaziz, S., Abd El Fatah, N. Role of Serum Bicarbonate and Lactate as a Predictor of Mortality in Critically Ill Patient with Sepsis. EKB Journal Management System, 2646; 2024(12): -. doi: 10.58675/2682-339X.2810

Role of Serum Bicarbonate and Lactate as a Predictor of Mortality in Critically Ill Patient with Sepsis

Al-Azhar International Medical Journal
Volume 2024, Issue 12, December 2024  XML
DOI: 10.58675/2682-339X.2810
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Authors
Amani Ali1; Seham Qutb1; Sara Abdelaziz2; Nada Abd El Fatah1
1Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
2Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Abstract
Background: Sepsis is a severe condition described by organ dysfunction due to infection and an abnormal host response, Aim: To assess the role of serum bicarbonate and lactate as a predictor of mortality in critically ill case with sepsis. Patients and methods: This prospective investigation has been performed on 80 critically-ill cases with sepsis have been divided into: Group I: (40 patient have sepsis with chronic illness) and Group II: (40 patient have sepsis without chronic illness) admitted to intensive care unit in AI Zahraa University Hospital from April 2023 to May 2024. Results: A statistically significant positive association was detected among bicarbonate (HCO3) and hematocrit test (HCT), PH and carbon dioxide (Co2), also statistically significant negative association among potassium (K) and HCO3 and statistically significant positive association among HR and lactate and total bilirubin in group one while in group two there was a statistically significant negative correlation among HCO3 and partial pressure of oxygen (PaO2), SOFA score, APACHE II score, lactate, urea and creatinine. Also, statistically significant positive association between HCO3 and PH and CO2 and a statistically significant positive correlation between lactate and SOFA score and PACHE II score. Conclusion: Serum lactate is the most accurate predictor of mortality in sepsis due to its strong association with SOFA score. Bicarbonate serum is also a good predictor of sepsis clinical outcomes, and low levels of bicarbonate negatively correlate with serum lactate, increasing morbidity and mortality in critically ill cases.
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