Comparative study between Plasma Level of Kisspeptin- 10 in Normal Pregnant and Preeclamptic Women | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2025, Issue 1, January 2025 | ||||
| DOI: 10.58675/2682-339X.2864 | ||||
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| Authors | ||||
| Albayoumi Fouda1; Mofeed Mohamed2; Ahmed Elsadek2 | ||||
| 1Medical Physiology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt | ||||
| 2Obstetrics and Gynecology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: The clinician's capacity to predict preeclampsia before the appearance of its symptoms has not improved yet. Objective: Comparing plasma levels of kisspeptin-10 in healthy pregnant women with those in women who develop preeclampsia during the second and third trimesters. Methods: From April 2021 to August 2022, researchers followed 90 pregnant women who had singleton pregnancies and completed the 20th week of their pregnancies and split them into three groups. Women with normal blood pressure (group I), those with mild PE (group II), and those with severe PE (group III) were each group given an equal number of participants (n=30). Plasma kisspeptin -10 levels were measured and compared between different groups during the second and third trimesters. Results: Compared to the control or mild PE groups, the plasma kisspeptin-10 levels in the severe PE groups were lower throughout the second or third trimester. Plasma kisspeptin-10 levels in the second trimester of severe preeclamptic women were inversely correlated with mean blood pressure only, whereas levels in the third trimester were found to be directly correlated with fetal birth weight. Conclusion: When determining the severity of preeclampsia KP -10 could be helpful. Screening is not advised for preeclampsia prediction due to insufficient test sensitivity. | ||||
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