Multi-Detector Computed Tomographic Evaluation of Pancreatic Volume and Fat Content in Type 2 Diabetic Patients
Kineber, A., Aun, A., Sedeek, A., Ali, A. (2645). Multi-Detector Computed Tomographic Evaluation of Pancreatic Volume and Fat Content in Type 2 Diabetic Patients. EKB Journal Management System, 2024(10), -. doi: 10.58675/2682-339X.2697
Abdullah Kineber; Abdelaziz Aun; Ahmed Sedeek; Ahmed Ali. "Multi-Detector Computed Tomographic Evaluation of Pancreatic Volume and Fat Content in Type 2 Diabetic Patients". EKB Journal Management System, 2024, 10, 2645, -. doi: 10.58675/2682-339X.2697
Kineber, A., Aun, A., Sedeek, A., Ali, A. (2645). 'Multi-Detector Computed Tomographic Evaluation of Pancreatic Volume and Fat Content in Type 2 Diabetic Patients', EKB Journal Management System, 2024(10), pp. -. doi: 10.58675/2682-339X.2697
Kineber, A., Aun, A., Sedeek, A., Ali, A. Multi-Detector Computed Tomographic Evaluation of Pancreatic Volume and Fat Content in Type 2 Diabetic Patients. EKB Journal Management System, 2645; 2024(10): -. doi: 10.58675/2682-339X.2697

Multi-Detector Computed Tomographic Evaluation of Pancreatic Volume and Fat Content in Type 2 Diabetic Patients

Al-Azhar International Medical Journal
Volume 2024, Issue 10, October 2024
DOI: 10.58675/2682-339X.2697
Authors
Abdullah Kineber1; Abdelaziz Aun2; Ahmed Sedeek2; Ahmed Ali3
1Radiology, Kafr Elsheikh Fever hospital, Kafr Elsheikh, Egypt
2Radiology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
3Internal Medicine, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
Abstract
Background: Pancreatic steatosis, characterized by excessive pancreatic fat accumulation, lacks a definitive and accurate diagnostic estimation method. Pancreas volume (PV) and fat content (PF) are potential indicators of pancreatic function, possibly changing with diabetes progression. Multidetector computed tomography (MDCT) provides a noninvasive tool for assessing pancreatic fat and volume. Objective: Evaluate MDCT's efficacy in estimating fat content and pancreatic volume in type 2 diabetics and its impact on diabetes characteristics. Patients and Methods: 50 participants were separated into groups: Group 1 with 25 type 2 diabetes patients and Group 2 with 25 age-sex-matched, non-obese, apparently healthy, non-diabetic subjects. Measurements included anthropometrics, diabetes duration, medications, and glycemic control, with MDCT used for PV and PF assessment. Results: Within the patient group, PV was significantly lower compared to controls (50.77 ± 12.77 cm³ vs. 68.08 ± 2.39 cm³, p = 0.006), while mean PF density, measured in Hounsfield units (HU), was significantly higher (-15.46 ± 3.15 HU vs. 5.31 ± 3.77 HU, p < 0.001). Also, PV was negatively related to age, BMI, waist circumference, diabetes duration, and HbA1c% (p=0.042, p=0.043, p=0.009, p=0.012, and p<0.001), while PF was positively related to these same things (p=0.026, p=0.024, p<0.001, p=0.009, and p=0.01, respectively). Conclusion: MDCT is an effective modality for estimating pancreatic fat content and pancreatic volume and underscores the strength of the association between type 2 diabetes mellitus and pancreatic steatosis.
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