Assessment of Cardiac Function Using Tissue Doppler in Patients with Beta-Thalassemia and Its Correlation to Serum Levels of Hepcidin in Egyptian Patients
El-Shennawy, A., Al- Habbaa, A., Nassar, Y., Ahmed, Y. (2646). Assessment of Cardiac Function Using Tissue Doppler in Patients with Beta-Thalassemia and Its Correlation to Serum Levels of Hepcidin in Egyptian Patients. EKB Journal Management System, 2024(12), -. doi: 10.58675/2682-339X.2801
Abd Allah El-Shennawy; Ahmed Al- Habbaa; Youssef Nassar; Youssef Ahmed. "Assessment of Cardiac Function Using Tissue Doppler in Patients with Beta-Thalassemia and Its Correlation to Serum Levels of Hepcidin in Egyptian Patients". EKB Journal Management System, 2024, 12, 2646, -. doi: 10.58675/2682-339X.2801
El-Shennawy, A., Al- Habbaa, A., Nassar, Y., Ahmed, Y. (2646). 'Assessment of Cardiac Function Using Tissue Doppler in Patients with Beta-Thalassemia and Its Correlation to Serum Levels of Hepcidin in Egyptian Patients', EKB Journal Management System, 2024(12), pp. -. doi: 10.58675/2682-339X.2801
El-Shennawy, A., Al- Habbaa, A., Nassar, Y., Ahmed, Y. Assessment of Cardiac Function Using Tissue Doppler in Patients with Beta-Thalassemia and Its Correlation to Serum Levels of Hepcidin in Egyptian Patients. EKB Journal Management System, 2646; 2024(12): -. doi: 10.58675/2682-339X.2801

Assessment of Cardiac Function Using Tissue Doppler in Patients with Beta-Thalassemia and Its Correlation to Serum Levels of Hepcidin in Egyptian Patients

Al-Azhar International Medical Journal
Volume 2024, Issue 12, December 2024
DOI: 10.58675/2682-339X.2801
Authors
Abd Allah El-Shennawy1; Ahmed Al- Habbaa2; Youssef Nassar1; Youssef Ahmed1
1Internal Medicine, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
2Cardiology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
Abstract
Background: The carrier rate for beta-thalassemia, an inherited hemoglobinopathy, ranges from approximately 1 to 11% in nations of the Mediterranean, Southeast Asia, North Africa, and the Middle East. Hemolytic anemia, inefficient erythropoiesis, and iron excess are symptoms of this condition, which is marked by the malfunction or loss of the β globin genes. Objective: To evaluate the relationship between diastolic dysfunction and serum hepcidin level, as well as to examine the effectiveness of TDI and PWD modalities in diagnosing early diastolic dysfunction prior to the onset of overt cardiomyopathy. Patients and Methods: This case-control study included 120 adults (aged 18 and up) who gave their informed consent after the study received approved from the department's ethical committee. The study's volunteers were split evenly between two groups: those who received TDT and those who were considered healthy. Includes patients without cardiac symptoms who have had transfusion-dependent transfusion therapy (TDT) for at least two years. Results: When looking at serum ferritin, E, E/E ratio, LVEDD, and hepcidin levels, a negative connection was seen. The results showed that serum hepcidin was positively correlated with E' but not with AO or LA diameters. Conclusion: The serum hepcidin level is lower in Egyptian beta-thalassemia patients with -TM, and it is inversely related to E and E/E', while it is positively correlated with E.' On the other hand, the serum ferritin level is higher in these patients, and it is inversely related to E and E/E', while it is positively correlated with E.
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