Corneal Thickness and Endothelial Changes by Noncontact Specular Microscope in Chronic Kidney Disease | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2024, Issue 10, October 2024 | ||||
| DOI: 10.58675/2682-339X.2709 | ||||
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| Authors | ||||
| Nashwa Saleh; Nour eldin Abdelhalim; Asmaa Youssef | ||||
| Ophthalmology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: A strong correlation was found between kidney and eye diseases. Hence, investigating the effect of renal failure on the corneal endothelium is important in planning intraocular surgeries. Aim and objectives: To evaluate central corneal thickness (CCT), people suffering from chronic kidney disease (CKD), and alterations affecting the endothelium using the noncontact specular microscope. Patients and methods: This observational cross-sectional study was carried out from September 2023 to March 2024. It comprised 63 eyes of 63 subjects who attended the outpatient clinics of Ophthalmology, internal medicine, and Nephrology in Al-Zahraa and Bab Al-Sharia, Al-Azhar University, Cairo, Egypt. Results: In the CCT, there was a statistically significant distinction (P=0.039) between the dialyzed groups (CCT: 531±30.5μm) and the control group (CCT: 506.4±24.5μm). There was no statistically significant variation in corneal endothelial cell density (ECD). In contrast to the non-dialyzed and control groups, the percentage of hexagonal cells (HEX%) in the dialyzed group was considerably lower at 52±6%, 58±3%, and 68±7%, respectively (P Conclusion: Patients with chronic kidney disease (CKD) may have morphological alterations in the corneal endothelium, such as polymegathism and pleomorphism, which could affect the outcome of intraocular surgery. Physician knowledge of these modifications may facilitate more effective intraocular surgery planning when necessary. | ||||
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