Study of serum Fatty Acid Binding Protein-1 levels in Diabetic Kidney Disease
Hemida, M., Ali, A., Mohammad, A., Yousef, S., Askar, B. (2646). Study of serum Fatty Acid Binding Protein-1 levels in Diabetic Kidney Disease. EKB Journal Management System, 2024(12), -. doi: 10.58675/2682-339X.2734
Mahmoud Hemida; Ahmed Ali; Abdelsalam Mohammad; Shereen Yousef; Basem Askar. "Study of serum Fatty Acid Binding Protein-1 levels in Diabetic Kidney Disease". EKB Journal Management System, 2024, 12, 2646, -. doi: 10.58675/2682-339X.2734
Hemida, M., Ali, A., Mohammad, A., Yousef, S., Askar, B. (2646). 'Study of serum Fatty Acid Binding Protein-1 levels in Diabetic Kidney Disease', EKB Journal Management System, 2024(12), pp. -. doi: 10.58675/2682-339X.2734
Hemida, M., Ali, A., Mohammad, A., Yousef, S., Askar, B. Study of serum Fatty Acid Binding Protein-1 levels in Diabetic Kidney Disease. EKB Journal Management System, 2646; 2024(12): -. doi: 10.58675/2682-339X.2734

Study of serum Fatty Acid Binding Protein-1 levels in Diabetic Kidney Disease

Al-Azhar International Medical Journal
Volume 2024, Issue 12, December 2024  XML
DOI: 10.58675/2682-339X.2734
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Authors
Mahmoud Hemida1; Ahmed Ali1; Abdelsalam Mohammad2; Shereen Yousef3; Basem Askar1
1Internal Medicine, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
2Clinical Pathology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
3Nephrology , Ahmed Maher Teaching Hospital, Cairo, Egypt
Abstract
Background: One of the major microvascular complications of both type 1 diabetes (T1DM) and type 2 diabetes (T2DM) is Diabetic Kidney Disease (DKD), often presenting as progressive proteinuria or, less commonly, as a non-proteinuric reduction in Glomerular Filtration Rate (GFR). Aim: To evaluate the diagnostic capability of serum fatty acid-binding protein 1 (FABP-1) levels in proteinuric versus non-proteinuric DKD. Methods: Ninety individuals were divided into three groups for this case-control study: Group I included 30 patients with diabetes mellitus (DM) (type 2 or1) with evidence of persistent proteinuric DKD, Group II comprised another 30 patients with DM (type 2 or1) with evidence of persistent non-proteinuric DKD, and Group III consisted of 30 healthy controls. The study was conducted at Al-Hussein University and Ahmed Maher Teaching Hospitals from March to December 2023. Results: FABP-1 Serum levels were markedly greater in both Group I & II than in the control group, with Group I demonstrating notably elevated levels compared to Group II. The duration of diabetes and urinary Albumin Creatinine Ratio levels in Group I showed a significant association with FABP-1 levels. ROC curve analysis determined that serum FABP-1, with a threshold of > 2.98 ng/ml, could identify proteinuric DKD with a specificity of 78.33% and a sensitivity of 93.33%. Conclusion: Serum levels of FABP1 correlated significantly with the duration of diabetes in DKD patients, distinguishing between proteinuric and non-proteinuric conditions with high sensitivity and moderate specificity.
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