Nailfold Microvascular Capillaroscopic Changes and Serum KL-6 Pneumoprotein in Systemic Sclerosis Associated Interstitial Lung Diseases
Al-Wajih, M., Ghit, M., Abou Nar, A., Hamoud, H. (2645). Nailfold Microvascular Capillaroscopic Changes and Serum KL-6 Pneumoprotein in Systemic Sclerosis Associated Interstitial Lung Diseases. EKB Journal Management System, 2024(10), -. doi: 10.58675/2682-339X.2642
Mahmood Al-Wajih; Mohamad Ghit; Abd El Raouf Abou Nar; Hesham Hamoud. "Nailfold Microvascular Capillaroscopic Changes and Serum KL-6 Pneumoprotein in Systemic Sclerosis Associated Interstitial Lung Diseases". EKB Journal Management System, 2024, 10, 2645, -. doi: 10.58675/2682-339X.2642
Al-Wajih, M., Ghit, M., Abou Nar, A., Hamoud, H. (2645). 'Nailfold Microvascular Capillaroscopic Changes and Serum KL-6 Pneumoprotein in Systemic Sclerosis Associated Interstitial Lung Diseases', EKB Journal Management System, 2024(10), pp. -. doi: 10.58675/2682-339X.2642
Al-Wajih, M., Ghit, M., Abou Nar, A., Hamoud, H. Nailfold Microvascular Capillaroscopic Changes and Serum KL-6 Pneumoprotein in Systemic Sclerosis Associated Interstitial Lung Diseases. EKB Journal Management System, 2645; 2024(10): -. doi: 10.58675/2682-339X.2642

Nailfold Microvascular Capillaroscopic Changes and Serum KL-6 Pneumoprotein in Systemic Sclerosis Associated Interstitial Lung Diseases

Al-Azhar International Medical Journal
Volume 2024, Issue 10, October 2024  XML
DOI: 10.58675/2682-339X.2642
View on SCiNiTO View on SCiNiTO
Authors
Mahmood Al-Wajih1; Mohamad Ghit1; Abd El Raouf Abou Nar2; Hesham Hamoud1
1Rheumatology and Rehabilitation, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
2clinical Pathology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
Abstract
Background: In order to determine how well nailfold videocapillaroscopy (NVC) measures the severity of interstitial lung disease (ILD) in patients with systemic sclerosis (SSc), this study set out to explain the correlation between NVC results and serum Krebs von den Lungen (KL-6) biomarker levels. Methods: Fifty patients with systemic sclerosis participated in this cross-sectional analytical study. The NVC characteristics considered in this study were capillary density (CD), capillary dimension, hemorrhages, and capillary morphology. Enzyme-linked immunosorbent assay (ELISA) kits were used to measure serum KL-6 levels. Results: The serum KL-6 level was significantly correlated with decreased CD and aberrant capillary morphology (r = -0.919; P < 0.01). Serum KL-6 level was moderately connected with capillaroscopic scleroderma pattern (r = 0.400; P =0.004), and the presence of megacapillaries was marginally correlated with serum KL-6 level (r = -0.294; P = 0.034). A significant correlation between the presence of hemorrhages and serum KL-6 levels was not seen (r = -0.039; P < 0.788). Conclusions: The study's findings suggest that NVC has promise as a method for SSc patients to gauge the severity of their ILD. There was a robust correlation between CD, aberrant capillary morphology, and serum KL-6 levels. Based on these findings, NVC may be useful in SSc patients as a primary or adjunctive lung involvement investigation. To confirm these results, larger-scale longitudinal studies are still required.
Statistics
Article View: 12