Serum Vitamin D Level and Biochemical metabolic Bone Markers and Their Relation to Disease Activity in Juvenile Idiopathic Arthritis | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2024, Issue 1, January 2024 | ||||
| DOI: 10.58675/2682-339X.2341 | ||||
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| Authors | ||||
| Mohamed I. AbdelKareem1; Mohamed M. Rayan1; Ali S. Mohamed2; Ahmed A. Rab El-Naby1 | ||||
| 1Rheumatology and Rehabilitation department, Faculty of Medicine - Al-Azhar University (Assiut) | ||||
| 2Clinical Pathology, Faculty of Medicine - Al-Azhar University (Assiut) | ||||
| Abstract | ||||
| Background: Juvenile idiopathic arthritis is an autoimmune disorder characterized by chronic joint inflammation. Aim: to determine the Serum vitamin D level and biochemical bone markers and their relation to disease activity in juvenile idiopathic arthritis. Patients and Methods: In a cross-sectional case control study, 80 children from those attending the outpatient clinic and inpatient of Rheumatology and Pediatric departments - Alazhar University (Assuit) hospital. Results: 25-(OH) vitamin that was significantly lower among those with systemic onset disease. Effusion was frequently found in all examined joints but knee joint was the most frequent affected joints (75%). Positive power Doppler was detected in 12 (15%), 12 (15%), 10 (8%) and 14 (17.5%) of wrist, elbow, knee and ankle joints, respectively. Based on x-ray findings were per-articular osteopenia followed by narrowing of joint space while the least finding was bone erosion Conclusion: Osteoporosis and vitamin D deficiency were a frequent complication of JIA. JIA Patients are likely to have low BMD. Duration of disease and BMI were more important factors in the development of low BMD in patients with JIA. Vitamin D deficiency and low BMD an alert to high risk for the development of osteoporosis and vitamin D deficiency later in life in these patients. | ||||
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