Study Of IL -17 As An Add-On Biomarker For Evaluation Of Lupus Nephritis Activity | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2023, Issue 1, January 2023 | ||||
| DOI: 10.58675/2682-339X.2106 | ||||
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| Authors | ||||
| Abdel Wahab Mohammed Lotfy1; Ibrahim Mohamed Rageh2; Farag Khalil1; Mahmoud Mostafa Kamel1 | ||||
| 1Department of Internal Medicine , Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt. | ||||
| 2Department of Clinical Pathology, Faculty of Medicine, Benha University, Kalubia, Egypt. | ||||
| Abstract | ||||
| Background: The Th17/IL-17 axis is characterized primarily by its effector and proinflammatory properties. Present serologic and urine indicators are not linked well with nephritic activity in systemic lupus erythematosus (SLE), despite the great efficacy of biomarkers for the diagnosis of SLE. Aim and objectives: we plan to study the role of adding IL-17 to C3 and C4 as a complementary indicator of lupus nephritis(LN) activity. Subjects and methods: This cross sectional observisional research, includes 60 patients selected from attendee of immunology and allergy center, AL-Azhar University. Results: there was a statistically significant variance amongst our research populations regarding contrast amongst ESR 1st H & CRP, C3 & C4, Contrast amongst the three examined groups regarding to Anti DNA & ANA and Contrast amongst the three examined groups regarding to IL-17 (ng/L). There was a statistically substantial negative association amongst IL- 17, C3 and C4 with p-value 0.001, and | ||||
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