Non-alcoholic Pancreatic Lipomatosis among the Egyptian type 2 Diabetic Patients

Mahrous, Abdel-Rahman; Al-Alfy, Mohammed; Abdel-Hassib, Mohammed; Amin, Mohammed

doi:10.58675/2682-339X.2449

	Non-alcoholic Pancreatic Lipomatosis among the Egyptian type 2 Diabetic Patients
Al-Azhar International Medical Journal
Volume 2024, Issue 12, December 2024
DOI: 10.58675/2682-339X.2449
View on SCiNiTO
Authors
Abdel-Rahman Mahrous; Mohammed Al-Alfy¹; Mohammed Abdel-Hassib¹; Mohammed Amin²
¹Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
²Diagnostic and Interventional Radiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Abstract
Background: Obesity has become a serious public health problem globally. Non-alcoholic pancreatic lipomatosis is characterized by pancreatic fat infiltration or pancreatic islet steatosis resulting in abnormal adipokine secretion, insulin resistance, impaired βcell function, and decreased insulin secretion. Aim: To assess the relationship between non-alcoholic fatty pancreatic disease and type 2 diabetes mellitus among Egyptian patients. Methods: We enrolled 80 type 2 diabetic patients along with 80 healthy control individuals, all were assessed by abdominal ultrasound and CT scan to determine the degree of pancreatic steatosis based on echogenicity of pancreatic tissue, and four-scale grading system as the visual assessment criteria for pancreatic fat deposition using CT images. Results: We found that the diabetic group demonstrated a prevalence of fatty pancreas accounting for 43.8% versus 7.5% in the healthy control group with a p-value <0.001. BMI, ALT, AST, amylase, lipase, ALT, AST, cholesterol, LDL, TG, and HbA1c were positively correlated with the degree of fatty pancreas. BMI, TG, and LDL levels are independent predictors for fatty pancreas after adjusting for other risk factors such as cholesterol level, HDL, and HBA1c with p values <0.01. BMI, ALT, AST, Hb A1c, and lipid profile can significantly predict a fatty pancreas. Conclusion: Pancreatic steatosis is significantly associated with type 2 diabetes, glycemic control, lipid profile, and body mass index. The degree of non-alcoholic pancreatic lipomatosis by CT scan significantly correlates with body mass index, lipid profile, and glycemic control.


Statistics Article View: 21