Terahertz Pulsed Spectroscopy for Optical and Dielectric Properties of Demineralized Bone Matrix, Collagen and Hydroxyapatite
Khalil, S., El hotaby, W., Bassyouni, G. (2019). Terahertz Pulsed Spectroscopy for Optical and Dielectric Properties of Demineralized Bone Matrix, Collagen and Hydroxyapatite. EKB Journal Management System, 62(Special Issue (Part 1) Innovation in Chemistry), 327-346. doi: 10.21608/ejchem.2019.14201.1876
Safaa Khalil; Walid El hotaby; Gehan Bassyouni. "Terahertz Pulsed Spectroscopy for Optical and Dielectric Properties of Demineralized Bone Matrix, Collagen and Hydroxyapatite". EKB Journal Management System, 62, Special Issue (Part 1) Innovation in Chemistry, 2019, 327-346. doi: 10.21608/ejchem.2019.14201.1876
Khalil, S., El hotaby, W., Bassyouni, G. (2019). 'Terahertz Pulsed Spectroscopy for Optical and Dielectric Properties of Demineralized Bone Matrix, Collagen and Hydroxyapatite', EKB Journal Management System, 62(Special Issue (Part 1) Innovation in Chemistry), pp. 327-346. doi: 10.21608/ejchem.2019.14201.1876
Khalil, S., El hotaby, W., Bassyouni, G. Terahertz Pulsed Spectroscopy for Optical and Dielectric Properties of Demineralized Bone Matrix, Collagen and Hydroxyapatite. EKB Journal Management System, 2019; 62(Special Issue (Part 1) Innovation in Chemistry): 327-346. doi: 10.21608/ejchem.2019.14201.1876

Terahertz Pulsed Spectroscopy for Optical and Dielectric Properties of Demineralized Bone Matrix, Collagen and Hydroxyapatite

Egyptian Journal of Chemistry
Article 25, Volume 62, Special Issue (Part 1) Innovation in Chemistry, December 2019, Page 327-346  XML PDF (1.95 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.14201.1876
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Authors
Safaa Khalil email orcid 1; Walid El hotabyorcid 1; Gehan Bassyouniorcid 2
1Spectroscopy Dept., Physics Div., National Research Centre, Dokki, Giza, Egypt
2Ceramic Research Dept., National Research Centre, Dokki, Cairo, Egypt
Abstract
Demineralized bone matrix (DBM) has osteoinductive potential functioning in many biological applications such as three-dimensional scaffold which assist new bone and cartilage growth by enhanced bioavailability of growth factors. Terahertz pulsed spectroscopy (TPS) was applied to investigate the optical and dielectric properties of camel femoral and cranial DBM, collagen type I, synthetic and natural hydroxyapatite powder (HA) in the range of 0.06-3.5THz. Terahertz (THz) absorption, refractive index (R.I) and dielectric properties (εʹ and εʺ) were found to be intensely differentiated to control and demineralized bone. Results presented the THz absorption fingerprint of all studied materials. The natural HA revealed higher R.I, εʹ, and εʺ values than both synthetic HA and collagen. Cranial DBM exhibited higher R.I compared to the control in all frequency ranges, whereas the femoral DBM behavior was frequency dependent. Demineralization produced significant increase in the values of εʹ and εʺ. THz dielectric properties acted as a sensitive predictor to the composition and microstructure of bone in different biological applications. Amalgamation of Infrared Spectroscopy and THz spectroscopy together with TGA, ICP and EDX can offer deep insight into the sample properties.
Keywords
Demineralized bone; collagen; Terahertz Spectroscopy; refractive index; Dielectric properties
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