Assessment of Anticarcinogenic Effect of Chrysin against Induced Oral Squamous Cell Carcinoma Compared to Cisplatin | ||||
| Al-Azhar Journal of Dentistry | ||||
| Volume 2024, Issue 1, January 2024 | ||||
| DOI: 10.58675/2974-4164.1639 | ||||
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| Authors | ||||
| Alaa E. E. Ahmed1; Amany M. Abdalla2; Adel A. Shouman3 | ||||
| 1B.D.S. (2011), M.Sc. (2019) Al-Azhar University, Assistant Lecturer of Oral Pathology -Al-Azhar University -Cairo, Egypt | ||||
| 2Lecturer of Oral and Dental Pathology, Faculty of Dental Medicine for Girls, Al-Azhar University- Cairo. | ||||
| 3Professor of Oral and Dental Pathology, Former Dean of the Faculty of Dental Medicine for Girls, Al-Azhar University- Cairo, Egypt, Former Dean of Faculty of Oral and Dental Medicine, Badr University- Cairo, Egypt | ||||
| Abstract | ||||
| Purpose: The objective of the current investigation was about to assess anticarcinogenic effect of chrysin on induced oral squamous cell carcinoma by using caspase3 as an apoptotic marker. Material and Methods: Thirty-five hamsters were used. divided into two groups. Group 1: 5 hamsters remained untreated. Group 2 (30 DMBA-received hamsters for 8 weeks) subdivided into Group 2A: 10 hamsters took DMBA and served as a positive control group. Group 2B: 10 DMBA-received hamsters for 8 weeks and treated with chrysin (50mg/kg b.w. orally/day) for another 8 weeks. Group 2C: 10 DMBA-received hamsters for 8 weeks injected with cisplatin (5mg/kg b.w.) for another 8 weeks Results: Comparing all groups according to caspase 3 expression revealed that the mean area percentage values show the statistically significant higher mean value of Caspase 3 area% in 2C group was, followed by 2B group and the lowest mean value in group 1 using ANOVA test. Conclusion: Chrysin is regarded as a promising anticarcinogenic agent against induced HBP squamous cell carcinoma. | ||||
| Keywords | ||||
| chrysin; DMBA; Squamous cell carcinoma; Caspase 3 | ||||
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