Evaluation of pulp response and formation of Dentin Bridge after capping with stem cells and MTA | ||
| Al-Azhar Journal of Dentistry | ||
| Volume 12, Issue 1, January 2025, Pages 9-16 PDF (784.3 K) | ||
| Document Type: Original Article | ||
| DOI: 10.58675/2974-4164.1652 | ||
| Authors | ||
| Mai S. Omar1; Maha A. Niazy2; Dina Elkassas3 | ||
| 1Assistant Lecturer at Operative Dentistry Department, Faculty of Oral and Dental Medicine Misr International University, Cairo, Egypt | ||
| 2Professor of Operative Dentistry Department, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt | ||
| 3Visiting Professor of Restorative Dentistry Department, Faculty of Oral and Dental Medicine Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia. Professor of Operative Dentistry, Faculty of Oral and Dental Medicine, Misr International University, Cairo, Egypt. | ||
| Abstract | ||
| Purpose: The objective of the current study was to assess the efficacy of direct pulp capping (DPC) with dental pulp stem cells (DPSCs) and MTA (Mineral Trioxide Aggregate) on formation of dentin bridge. Materials and Methods: forty teeth from dogs were included in the current study. Preparation of Class V cavities was done followed by pulp exposure for the application of the (DPC) materials. Two groups of teeth consisting of 20 teeth in each in accordance with the (DPC) material used either MTA or DPSCs (N=20) were used. Afterwards, teeth were restored with glass ionomer as a final restoration. Histopathological evaluation was done after two-time intervals of 1 week and 45 days. Results: Regarding the capping materials, the results showed that there was inflammatory cell response for both materials at both time intervals. (DPSCs) showed mild inflammation at 1 week and 45 days while MTA showed moderate inflammation at 1 week and mild inflammation after 45 days. There was a statistically significant difference at 1week between both groups while after 45days there was no statistically significant difference between both groups. Regarding the formation of dentin bridge in DPSCs group there was no statistically significance at 1 week while after 45 days there was statistically significant difference. Dentin bridge formation was absent in both groups at 1 week while after 45 days it was formed in both groups. Conclusion: Among both groups (DPSCs) showed higher significant difference and considered one of the best direct pulp capping options. | ||
| Keywords | ||
| direct pulp capping; Mineral trioxide aggregate; Dental pulp stem cells; Dentin bridge formation | ||
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