Evaluation of 3D Computer-Assisted Patient’s Specific Scaffold Seeded with Autogenous Stem Cells and Platelet-Rich Fibrin in Alveolar Cleft Repair
Abd El Azeem, A., Al-Ahmady, H., Abdul Rahman, M. (2000). Evaluation of 3D Computer-Assisted Patient’s Specific Scaffold Seeded with Autogenous Stem Cells and Platelet-Rich Fibrin in Alveolar Cleft Repair. EKB Journal Management System, 8(2), 261-270. doi: 10.21608/adjg.2021.22943.1225
Ahmad Abd El Azeem; Hatem Al-Ahmady; Mostapha Abdul Rahman. "Evaluation of 3D Computer-Assisted Patient’s Specific Scaffold Seeded with Autogenous Stem Cells and Platelet-Rich Fibrin in Alveolar Cleft Repair". EKB Journal Management System, 8, 2, 2000, 261-270. doi: 10.21608/adjg.2021.22943.1225
Abd El Azeem, A., Al-Ahmady, H., Abdul Rahman, M. (2000). 'Evaluation of 3D Computer-Assisted Patient’s Specific Scaffold Seeded with Autogenous Stem Cells and Platelet-Rich Fibrin in Alveolar Cleft Repair', EKB Journal Management System, 8(2), pp. 261-270. doi: 10.21608/adjg.2021.22943.1225
Abd El Azeem, A., Al-Ahmady, H., Abdul Rahman, M. Evaluation of 3D Computer-Assisted Patient’s Specific Scaffold Seeded with Autogenous Stem Cells and Platelet-Rich Fibrin in Alveolar Cleft Repair. EKB Journal Management System, 2000; 8(2): 261-270. doi: 10.21608/adjg.2021.22943.1225

Evaluation of 3D Computer-Assisted Patient’s Specific Scaffold Seeded with Autogenous Stem Cells and Platelet-Rich Fibrin in Alveolar Cleft Repair

Al-Azhar Journal of Dentistry
Volume 8, Issue 2, April 2021, Pages 261-270    PDF (676.78 K)
Document Type: Original Article
DOI: 10.21608/adjg.2021.22943.1225
Authors
Ahmad Abd El Azeem1; Hatem Al-Ahmady2; Mostapha Abdul Rahman1
1Oro-dental Genetics Department, Human Genetics and Genome Research Division, National Research Centre
2Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine for girls Al-Azhar University
Abstract
Purpose: Evaluation of the treatment outcome of using patient-specific implantable scaffolds seeded with autogenous bone marrow mononuclear cell layer containing stem cells and platelet-rich fibrin in the treatment of alveolar cleft defect. Materials and methods: 12 alveolar cleft defects were divided into 2 groups; group A, six alveolar defects were treated using 3D printed patient’s specific implantable PLLA scaffolds seeded with autogenous bone marrow mononuclear cell layer containing stem cells and platelet-rich fibrin. Group B, six alveolar defects were treated with standard anterior iliac crest cortico-cancellous alveolar bone grafting procedures. Clinical and radiographic assessments were done to compare between two groups. Results: The results Showed that after 6 months group A was radiographically significantly less dense than the autogenous grafting group and when compared to Bergland’s scale there was no significant difference in bone loss after 6 months. Conclusion: Although this technique may not be the best choice regarding the density of bone formation, however within the limitations of this study, the results showed that this technique may be a new solution for transformation of the persistent cases of chronic oronasal fistula patients who underwent multiple failed autogenous bone grafting from a state of chronic fistulation to normal alveolar bone augmentation candidates.
Keywords
Alveolar cleft; stem cells; 3D printing; Scaffold
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