Effect of Bone Marrow Derived-Mesenchymal Stem Cells on Submandibular Salivary Glands of Carbimazole Induced Hypothyroidism in Albino Rats | ||||
| Al-Azhar Journal of Dentistry | ||||
| Volume 2021, Issue 2, April 2021 | ||||
| DOI: 10.21608/adjg.2021.29129.1252 | ||||
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| Authors | ||||
| dina el dahrawy1; Heba Adawy2; mona eldeeb3 | ||||
| 1Teaching assistant of Oral Biology, Oral Biology Department, Faculty of Oral and Dental Medicine, Future University in Egypt. | ||||
| 2Professor of Oral Biology, Oral Biology Department, Faculty of Dental Medicine for Girls, Al –Azhar University. | ||||
| 3Professor of Oral Biology, Oral biology Department, Faculty of Oral and Dental Medicine, Future University in Egypt. | ||||
| Abstract | ||||
| Purpose: This study was aimed to estimate the effect of bone marrow derived mesenchymal stem cells (BM-MSCs) on the submandibular salivary gland of induced hypothyroidism in rats. Material and Methods: Thirty adult male albino rats weighing between 200-250 grams were used in the present study. The animals were divided into three equal groups: Group I (control group), Group II (carbimazole induced hypothyroidism group): Rats received a daily dose of carbimazole (5mg/250g/day) for 5 weeks, Group III (BM-MSCs treated group): Hypothyroidism was induced similar to group II, then rats were injected with 1x 107 BM-MSCs cells. All Rats were euthanized after 8 weeks (5 weeks of hypothyroidism induction + 3 weeks of stem cells injection). Results: group (II) showed excessive destruction and degenerative changes of the acini and ducts in comparison to group (I), while group (III) revealed marked improvement of the parenchymal elements after BM-MSCs injection. Conclusions: This study supposes that BM-MSCs improve salivary glands damage following induction of hypothyroidism. Therefore, BM-MSCs can be applied as cell-based therapy for restoration of hypothyroid-induced salivary hypofunction. | ||||
| Keywords | ||||
| Bone marrow derived mesenchymal stem cells; Submandibular salivary gland; Carbimazole; hypothyroidism | ||||
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