Molecular Assessment of Kallikrein 3 in Ameloblastoma and Odontogenic Keratocyst | ||
| Al-Azhar Journal of Dentistry | ||
| Volume 10, Issue 1, January 2023, Pages 113-121 PDF (1.49 M) | ||
| Document Type: Original Article | ||
| DOI: 10.58675/2974-4164.1479 | ||
| Authors | ||
| Kholoud Ahmed* 1; Mohamed El Sebie2; Nadia Radi3; Amal Abd El Rahman4; Eman AboHager5 | ||
| 1Oral pathology, faculty of dentistry, Ahram candian university, 6th of October city, Egypt | ||
| 2Lecturer of medical biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt. | ||
| 3Associate Professor of Oral and Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt. | ||
| 4Professor of Oral and Maxillofacial Pathology, Faculty of Dentistry, Cairo University, Cairo, Egypt | ||
| 5Professor and Head of Oral and Dental pathology Department Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo Egypt | ||
| Abstract | ||
| Purpose: The current research was conducted to assess KLK3 at molecular and protein level in AB and OKC to shed more light on its role on biologic behaviour of these lesions. Material and methods: 30 paraffin embedded blocks of AB, OKC and Dentigerous Cyst (DC) as a control were included. Immunohistochemical staining technique with KLK3 antibody was applied to all the tissue blocks and RT-PCR KLK3 gene were done for all specimens. Results: The mean area percent of KLK3 expression was significantly greater in AB and OKC compared with DC. According to the current study, presence of significant difference between AB and OKC in relation to control indicates that KLK3 antibody is related the aggressive biologic behaviour of AB and OKC. Conclusion: Increased expression of KLK3 protein and gene expression in AB and OKC suggests that KLK3 may have a role in the intrinsic and limitless growth potential of these lesions. | ||
| Keywords | ||
| Ameloblastoma; Odontogenic Keratocyst; KLK3 | ||
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