Black Garlic Extract Polyphenols Constituents Adjuvant to Low Doses of Gamma Irradiation Exhibit Oxidative Stress on Murine Tumor
Ahmed, N., Shedid, S., Abd ElWahab, S., rabia, F. (2025). Black Garlic Extract Polyphenols Constituents Adjuvant to Low Doses of Gamma Irradiation Exhibit Oxidative Stress on Murine Tumor. EKB Journal Management System, 38(1), 25-38. doi: 10.21608/ejrsa.2025.333983.1177
Neamat Hanafi Ahmed; Shereen Shedid; Safaa Abd El Wahab Abd ElWahab; fatma rabia. "Black Garlic Extract Polyphenols Constituents Adjuvant to Low Doses of Gamma Irradiation Exhibit Oxidative Stress on Murine Tumor". EKB Journal Management System, 38, 1, 2025, 25-38. doi: 10.21608/ejrsa.2025.333983.1177
Ahmed, N., Shedid, S., Abd ElWahab, S., rabia, F. (2025). 'Black Garlic Extract Polyphenols Constituents Adjuvant to Low Doses of Gamma Irradiation Exhibit Oxidative Stress on Murine Tumor', EKB Journal Management System, 38(1), pp. 25-38. doi: 10.21608/ejrsa.2025.333983.1177
Ahmed, N., Shedid, S., Abd ElWahab, S., rabia, F. Black Garlic Extract Polyphenols Constituents Adjuvant to Low Doses of Gamma Irradiation Exhibit Oxidative Stress on Murine Tumor. EKB Journal Management System, 2025; 38(1): 25-38. doi: 10.21608/ejrsa.2025.333983.1177

Black Garlic Extract Polyphenols Constituents Adjuvant to Low Doses of Gamma Irradiation Exhibit Oxidative Stress on Murine Tumor

Egyptian Journal of Radiation Sciences and Applications
Volume 38, Issue 1, December 2025, Pages 25-38    PDF (1.67 M)
Document Type: Original Article
DOI: 10.21608/ejrsa.2025.333983.1177
Authors
Neamat Hanafi Ahmed* 1; Shereen Shedid2; Safaa Abd El Wahab Abd ElWahab3; fatma rabia4
1Radiation Biology Department, National Center for radiation Research and Technology, Egyptian Atomic Energy Authority
2Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt
3Food Irradiation Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
4atomic energy authority
Abstract
Background: with precisely controlled degrees of moisture and heat the color of raw garlic turn black. Black garlic have a strong role in preventing cancer. Also, low doses of γ-radiation exposure induce a positive impact on tumor regression and immune response. Methodology: the present study evaluates the leverages of black garlic extract polyphenols (BGE) and/or low doses of γ-irradiation against Ehrlich (Eh) carcinoma-bearing mice. Results: the in-vitro cytotoxic effect test showed that, BGE (60 µg / ml) produced the death of 100% of Ehrlich Ascites Carcinoma (EAC) cells and 30% of cells appeared to burst. Subcutaneous transplantation of 2.5x106 EAC cells in female mice produced a solid Eh carcinoma. Via gavages 15 consecutive treatments of BGE (200mg/kg. b.w./day) and the subject of experimental animals to γ-radiation (0.25Gy x 2/ week) for two weeks from the 7th day of tumor inoculation recording that BGE and/or γ-radiation reduced tumor size significantly and markedly amended most alterations in biochemical parameters associated with Eh carcinoma inoculation. Conclusion: the BGE gavages to mice bearing Eh carcinoma, exhibited an antitumor effect reflected by reducing tumor size, inhibiting systemic inflammation, and augmenting the antioxidant defense system in Eh carcinoma-bearing mice.
Keywords
black garlic extract polyphenols; Ehrlich Carcinoma; low doses of γ-irradiation; cytotoxicity; systemic inflammation; antioxidant defense system
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