Prevalence of Celiac Disease Among School-Age Children with Isolated Short Stature | ||
| Zagazig University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 07 July 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2025.391444.3986 | ||
| Authors | ||
| Ehab Mahmoud Rasheed1; Samar Mahmoud Abdelhalim2; Ibrahim Mohamed Ibrahim Ali* 3; Ghada Mohammed Abdellatif4 | ||
| 1Professor of Pediatrics Department, Faculty of Medicine, Zagazig University, Egypt | ||
| 2Professor of Clinical Pathology , Faculty of Medicine, Zagazig University, Egypt | ||
| 3Pediatrics Department, Faculty of Medicine, Zagazig University, Egypt | ||
| 4Lecturer of Pediatrics Department, Faculty of Medicine, Zagazig University, Egypt | ||
| Abstract | ||
| Background: Celiac disease (CeD) is an immune-mediated intestinal disorder triggered by gluten in genetically susceptible individuals. In some cases, short stature (SS) may be the only presenting sign, with or without gastrointestinal (GI) symptoms. This study aimed to determine the prevalence of celiac disease in children with isolated short stature. Methods: This cross-sectional study included 96 school-aged children (6–16years) with isolated short stature (height for age <-2SD). Participants were divided into two groups: group I (6 patients with CeD; 4 males, 2 females, mean age 7±1 years) and group II (90 patients without CeD; 47 males, 43 females, mean age 6–14 years). All underwent detailed history, physical examination, anthropometric assessment, routine and specific laboratory tests for CeD including total IgA and anti-tissue transglutaminase IgA (anti-TTG IgA) via ELISA. Children with positive serology had upper GI endoscopy and duodenal biopsy for confirmation. Results: Among 96 children, 6 (6.3%) had high anti-TTG IgA levels and 90 ones (93.8%) had normal anti-TTG IgA levels also there was a significant correlation between biopsy results and serum IgA and anti-TTG IgA levels. All celiac patients had increased anti-TTG IgA levels and their diagnosis was confirmed by upper GIT endoscopy and biopsy. Conclusion: celiac disease is common in children with isolated short stature, and it is crucial to test all such children by measuring anti TTG antibodies as early diagnosis of celiac disease in children with isolated short stature can significantly improve growth velocity, enabling timely interventions that prevent long-term developmental and health complications | ||
| Keywords | ||
| Celiac disease; Gastrointestinal; Children; Short stature | ||
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