The Role of Beta-2-Microglobulin as an Early Predictor for Renal Dysfunction in Petrol Station Workers in Fayoum Governorate, Egypt
saleh, A., Algalad, G., Ragab, M., Roby, M., Elsayed, A. (2025). The Role of Beta-2-Microglobulin as an Early Predictor for Renal Dysfunction in Petrol Station Workers in Fayoum Governorate, Egypt. EKB Journal Management System, (), -. doi: 10.21608/zjfm.2025.387399.1217
amro abdelghany saleh; Ghada Algalad; Mohamed Ragab; Mohamed Roby; Ahmed Elsayed. "The Role of Beta-2-Microglobulin as an Early Predictor for Renal Dysfunction in Petrol Station Workers in Fayoum Governorate, Egypt". EKB Journal Management System, , , 2025, -. doi: 10.21608/zjfm.2025.387399.1217
saleh, A., Algalad, G., Ragab, M., Roby, M., Elsayed, A. (2025). 'The Role of Beta-2-Microglobulin as an Early Predictor for Renal Dysfunction in Petrol Station Workers in Fayoum Governorate, Egypt', EKB Journal Management System, (), pp. -. doi: 10.21608/zjfm.2025.387399.1217
saleh, A., Algalad, G., Ragab, M., Roby, M., Elsayed, A. The Role of Beta-2-Microglobulin as an Early Predictor for Renal Dysfunction in Petrol Station Workers in Fayoum Governorate, Egypt. EKB Journal Management System, 2025; (): -. doi: 10.21608/zjfm.2025.387399.1217

The Role of Beta-2-Microglobulin as an Early Predictor for Renal Dysfunction in Petrol Station Workers in Fayoum Governorate, Egypt

Zagazig Journal of Forensic Medicine and Toxicology
Articles in Press, Accepted Manuscript, Available Online from 07 July 2025  XML
Document Type: Original Article
DOI: 10.21608/zjfm.2025.387399.1217
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Authors
amro abdelghany saleh email orcid 1; Ghada Algaladorcid 2; Mohamed Ragab3; Mohamed Robyorcid 4; Ahmed Elsayedorcid 5
1Forensic medicine and Clinical toxicology department- Faculty of medicine- Fayoum University
2Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Fayoum University
3Department of Forensic medicine and Clinical Toxicology- Faculty of medicine, Fayoum University, Fayoum- Egypt.
4Food Science and Technology Department, Faculty of Agriculture, Fayoum University- Fayoum- Egypt.
5Department of Forensic medicine and Clinical Toxicology - Faculty of Medicine- Fayoum University- Fayoum- Egypt.
Abstract
A B S T R A C T:
Background: Fuel station workers are exposed to hydrocarbon mixtures in fuel vapours and vehicular exhaust, which can lead to both acute and chronic health risks. Most fuel products pose risks to multiple organ systems, particularly the kidneys, due to the release of harmful metabolites like reactive oxygen species. β2-microglobulin (β2-MG) is particularly valuable in distinguishing between various forms of renal diseases. Aim: This study aimed primarily to measure urinary Beta-2-Microglobulin and assess its possible role as an early predictor of renal dysfunction in benzene filling workers. Methods: A prospective case-control study was conducted from March to December 2023, involving 120 participants (90 benzene-filling workers and 30 healthy controls) in the Fayoum governorate. In each participant, age, and working duration were recorded. Moreover, kidney function tests, serum hydrocarbon level using gas-chromatography coupled to mass-spectrometry (GC-MS), and urinary β2-MG were performed. Results: Statistically significant differences were found between the study and control groups regarding serum urea, serum creatinine, serum hydrocarbon levels, and urinary β2-MG. Notable correlations were observed between β2-MG and age, work duration, serum creatinine, and hydrocarbon levels. Conclusion: β2-MG shows potential as an early indicator of renal dysfunction among benzene workers, with a sensitivity of 92.1% and specificity of 78.0% for identifying renal tubular dysfunction.
Keywords
Gas chromatography-Mass spectrometry; Hydrocarbons; Kidney; β2-microglobulin
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