Evaluation of bone regeneration enhancement by in-vivo study using MAPTMS. | ||||
| New Valley University Journal of Basic and Applied Sciences | ||||
| Volume 3, Issue 1, June 2025, Page 67-77 PDF (1.9 MB) | ||||
| Document Type: Original papers | ||||
| DOI: 10.21608/nujbas.2025.380531.1043 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Mohamed Salah El-khooly  
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| Physics Dep., Faculty of Science, New Valley University, El Kharga, 72512, New Valley, Egypt. | ||||
| Abstract | ||||
| In this study, we employ 3-methacryloxypropyl trimethoxy silane (MAPTMS), an organic substance made using the sol-gel technique, which has been assessed as a bioactive bone substitute. An ethanol/water solution was used to achieve hydrolysis and condensation. The functional groups, crystal structure, and morphology were confirmed employing several techniques, including infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. The bioactivity of this sample was studied via in-vivo test by implanting the samples inside the tibia of rats for 1, 4, and 8 weeks. Results showed that the grafting materials used in repairing the bone defects do not cause histopathology with the peripheral osseous tissue because all animals lived without experiencing any local or general issues. The results also showed, after comparing the control sample (a group of rats) to which the same operation was performed without MAPTMS, that the group to which MAPTMS was applied had better bone tissue healing and recovery than the control sample. | ||||
| Keywords | ||||
| Biomaterials; In-vivo; Sol-gel; Bone regeneration; MAPTMS | ||||
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