Ameliorative Effects of Quercetin Nanoparticles and all trans retinoic acid -Preconditioned Mesenchymal Stem Cells on Doxorubicin-Induced Nephrotoxicity in Rats | ||||
| Mansoura Journal of Chemistry | ||||
| Volume 68, Issue 3, September 2025, Page 35-40 PDF (649.83 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcc.2025.398247.1018 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Ahmed Khedr Nasr 
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| Biochemistry, Faculty of science, Mansoura university, Mansoura egypt | ||||
| Abstract | ||||
| kidneys are essential organs responsible for the excretion of metabolic waste products, including urea, creatinine, and uric acid, with the nephron serving as their functional unit. Nephrotoxicity refers to impaired renal function or structural integrity, commonly induced by chemotherapeutic agents such as doxorubicin (DOX), which exerts its toxic effects via oxidative stress-mediated damage to renal tissue. Our study aimed to evaluate the potential renoprotective and antioxidant effects of quercetin nanoparticles (QuNPs) and mesenchymal stem cells (MSCs) preconditioned with all-trans retinoic acid (ATRA) in mitigating DOX-induced renal injury. Five experimental groups of rats were examined: control, DOX-treated, DOX+QuNPs, DOX+MSCs+ATRA, and a combination therapy group (Mix). Oxidative stress biomarkers, including malondialdehyde (MDA) and reduced glutathione (GSH), were measured in kidney tissue. Results demonstrated that MSCs+ATRA conferred greater renoprotection than QuNPs alone, while the greatest therapeutic effect was observed in the combination treatment group. These findings confirm the antioxidant and nephroprotective potential of QuNPs and ATRA-preconditioned MSCs against chronic DOX-induced kidney damage. | ||||
| Keywords | ||||
| Nano quercetin; MSCs; ATRA; Nephrotoxicity | ||||
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