Neuroprotective Effects of Quercetin Nanoparticles and all trans retinoic acid -Preconditioned Mesenchymal Stem Cells Against Doxorubicin-Induced Neurotoxicity in Rats | ||||
| Mansoura Journal of Chemistry | ||||
| Volume 68, Issue 3, September 2025, Page 41-47 PDF (744 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcc.2025.398266.1019 | ||||
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| Author | ||||
Sara Zaghloul Rizk 
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| Biochemistry, Faculty of science, Mansoura university, Mansoura, Egypt | ||||
| Abstract | ||||
| Brain, one of the most complex biological systems, is responsible for regulating essential functions such as sensory processing, motor control, cognition, language, emotion, and memory. A common chemotherapy drug, doxorubicin (Dox), causes oxidative stress in brain tissue, which raises reactive oxygen species (ROS) and causes neuroinflammation and neuronal death. When xenobiotics interfere with neurochemical signaling pathways, they can cause neurotoxicity by altering the structure and function of neurons. The current study aimed to evaluated the therapeutic potential of quercetin nanoparticles (QuNPs) and mesenchymal stem cells (MSCs) preconditioned with all-trans retinoic acid (ATRA) in mitigating DOX-induced oxidative stress in rat brain tissue. Five groups were studied: control, DOX, DOX+QuNPs, DOX+MSCs+ATRA, and a combined treatment group (Mix). Oxidative stress markers including malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH) were quantified. Results demonstrated that the MSCs+ATRA group exhibited greater neural recovery than the QuNPs group, with the most significant neuroprotective effect observed in the combined treatment group. These findings underscore the synergistic antioxidant and neuroprotective properties of QuNPs and MSCs+ATRA in counteracting DOX-induced neurotoxicity. | ||||
| Keywords | ||||
| Nano quercetin; MSCs; ATRA; Neurotoxicity | ||||
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