Effect Of Psidium Guajava And Artemisia annua Leaves On Nephrotoxic In Experimental Rats | ||||
| مجلة دراسات وبحوث التربية النوعية | ||||
| Volume 11, Issue 3 - Serial Number 29, July 2025, Page 153-190 PDF (2.32 MB) | ||||
| Document Type: المقالة الأصلية | ||||
| DOI: 10.21608/jsezu.2025.440462 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Gehan Ibrahem Adelwahab | ||||
| Home Economic Departments- Faculty of Specific Education -Ain shams University | ||||
| Abstract | ||||
| The current study looked at the preventive effects of aqueous extracts of Psidium guajava leaves (EEPGL) and Artemisia annua on gentamicin-induced nephrotoxicity in rats. Thirty-six male albino rats were separated into two major groups as follows: (The first core group of six rats) This primary group was fed a basal diet and served as the control group. (The second major group (30 rats): This main group was fed a basal diet and administered gentamicin (GM) intraperitoneally at a dose rate of 80 mg/kg body weight of rat for 8 consecutive days to induce nephrotoxicity. The rats in the second major group (30 rats) were then divided into into five subgroups (each group had six rats) as follows:Group 1 was fed on B.D. and kept as the control (+ve) group.Group 2: fed on B.D. and treated with 250 mg/kg b.w. of guava leaf aqueous extract daily; Group 3: fed on B.D. and treated with 500mg/kg b.w. of guava leaf aqueous extract daily; Group 4: fed on B.D. and treated with Artemisia extract orally 100 mg/kg b.w. daily; and Group 5: fed on B.D. and treated with Artemisia extract orally 200 mg/kg b.w. daily. The current studies demonstrated that guava 500 mg/kg normalized AST, ALT, and ALP similarly to healthy control, while Artemisia 200 mg/kg exhibited comparable efficacy.Guava 500 mg/kg reduced serum urea, uric acid and creatinine, while Artemisia 200 mg/kg achieved near-normal levels of urea, uric acid and creatinine. Both Psidium guajava and Artemisia annua extracts demonstrated significant nephroprotective and hepatoprotective effects against gentamicin-induced toxicity. Higher doses (500 mg/kg guava, 200 mg/kg Artemisia) were most effective, restoring biochemical, histological, and antioxidant parameters to near-normal levels. | ||||
| Keywords | ||||
| Psidium Guajava; Artemisia annua; Nephrotoxic | ||||
|
Statistics Article View: 50 PDF Download: 30 |
||||
