Possible role of inflammatory serum biomarkers in differentiation between epileptic seizure and psychogenic non-epileptic seizure. | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Articles in Press, Accepted Manuscript, Available Online from 09 July 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2025.373206.2500 | ||||
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| Authors | ||||
Yousra M Mammdoh1; Esraa Mostafa Ahmed  1; Hanan O Mohamed1; Amal A Mahmoud1; Mohamed A Abdelhamed2; Mohamed Mostafa Shehab2; Hala saleh Abdalghafour1
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| 1Clinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| 2Neuro-psychiatric Department, Neuro-epidemiology Lab., Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Psychogenic non-epileptic seizures (PNES), which Corresponding to epileptic seizures (ES), are often exaggerated, leading to intensive long-term use of antiepileptic drugs. Video electroencephalography (EEG) is considered the gold standard for identification; however, its availability is limited in many centers. The study objects is to check the neuroinflammatory biomarkers (monocyte chemoattractant protein-2 (MCP-2)/chemokine (CC motif) ligand 8 (CCL8) and tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL)) for their distinguishing capability among (ES) patients and patients with (PNES). Two serum markers were measured by Enzyme-linked immunosorbent assay in samples from 30 cases with ES, 30 cases diagnosed with PNES, and 28 healthy control population with the same age, gender, and ethnicity. The results of this study show that serum TRAIL levels were significantly elevated in the PNES group in comparison to the ES and control groups. Although, serum MCP -2/CCL8 levels were significantly higher in ES group compared to the PNES and control groups. | ||||
| Keywords | ||||
| epileptic seizures; psychogenic; ELISA; TRAIL; MCP-2/CCl-8 | ||||
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