Significance of CD105 Expression in Clear Cell Renal Cell Carcinoma (Immunohistochemical Study) | ||||
| Benha Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 09 July 2025 PDF (857.9 K) | ||||
| Document Type: Editorial | ||||
| DOI: 10.21608/bmfj.2025.290305.2084 | ||||
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| Authors | ||||
Nehal Saad Zafer1; Tagreed Abd El Samea Abdel Aziz2; Ghada Ahmed Abd-Elfattah3; Sara Nabil Nasif4; Sarah Hameed Sherif  5
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| 1Department of pathology, Faculty of Medicine, Benha University | ||||
| 2Department of Pathology, Faculty of Medicine, Benha University | ||||
| 3Department of Pathology Faculty of Medicine- Benha University-Egypt | ||||
| 4Department of Pathology, Faculty of Medicine- Benha University, Banha University | ||||
| 5(M.B.B.Ch, Faculty of Medicine, Benha University) (Resident Doctor of Pathology, Benha Educational Hospital) | ||||
| Abstract | ||||
| Background: Renal cell carcinoma (RCC) poses significant challenges due to its increasing incidence, mortality rates, and poor response to traditional therapies. Identifying diagnostic biomarkers and therapeutic targets, particularly in cancer stem cells (CSCs), remains crucial. CD105, associated with tumor growth and angiogenesis, has emerged as a potential prognostic marker and CSC identifier in RCC. This study aimed to evaluate the role of CD105 expression in ccRCC and to correlate the findings with the available clinicopathological data. Material and Methods: Fifty cases of cc RCC and ten non-neoplastic renal tissue controls were studied using archival blocks processed between 1993 and 2005. Histopathological classification followed the WHO 2016 guidelines, assessing nuclear grading, invasion, staging, and immunohistochemical staining for CD105 expression. A semiquantitative scoring system and H-score were employed to evaluate tumoral CD105 expression. Vascular density determined endothelial CD105 expression. Results: The study revealed associations between high endothelial CD105 expression and grade II/IV RCC, tumor necrosis, and lymph node invasion (p75% positive cells; p=0.045).CD105 showed 31.6% sensitivity and 71% specificity for Stage of ccRCC. Conclusion: D105 expression in ccRCC demonstrated correlations with certain clinicopathological factors, primarily endothelial CD105 expression with higher grades and tumor aggressiveness. However, tumoral CD105 expression lacked significant associations, emphasizing the need for further exploration of CD105's role as a prognostic marker in RCC. | ||||
| Keywords | ||||
| CD105; Expression; Clear Cell; Renal Cell; Carcinoma | ||||
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