Correlation Between Serum Prolactin Level and TSH Level in Newly Diagnosed Egyptian People with Subclinical Hypothyroidism

Abd El-Ghany, Mohammed Ibrahim; Abdelsalam, Sherehan Adel

doi:10.21608/bmfj.2025.381220.2394

	Correlation Between Serum Prolactin Level and TSH Level in Newly Diagnosed Egyptian People with Subclinical Hypothyroidism
Benha Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 09 July 2025 PDF (886.12 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2025.381220.2394
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Authors
Mohammed Ibrahim Abd El-Ghany ¹; Sherehan Adel Abdelsalam²
¹Department of Internal Medicine (Endocrinology & Diabetes unit), Faculty of Medicine, Mansoura University, Mansoura, Egypt.
²Department of Public Health and Community Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abstract
Background: Hyperprolactinemia is present in a wide range of subclinical hypothyroidism (SCH) patients, from 0% to 40%. We aimed to find out the prevalence of hyperprolactinemia in newly diagnosed SCH subjects. Also, to estimate and correlate serum prolactin (PRL) levels in subjects with SCH. Methods: Three hundred participants, 200 SCH subjects, and 100 normal subjects aged 18 to 45 were classified into 3 groups according to TSH levels and compared. Group A includes 100 subjects with TSH levels (4.5 to 7.49 uIU/L). Group B includes 100 subjects with TSH levels (7.5 to 10 uIU/L). Group C includes 100 subjects with normal TSH levels. Detailed clinical history was taken. Also, serum PRL, anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-TG) levels were obtained. Results: The prevalence of hyperprolactinemia in SCH subjects was 22.5%. Hashimoto’s thyroiditis represents 40% of SCH cases. There was a significant positive correlation between PRL level and the TSH (r=0.350), Anti-TPO (r=0.374), anti-TG (r=0.374), and BMI (r=0.381). Multivariate analysis demonstrates an increase in TSH level by one unit increases the risk of hyperprolactinemia by 1.79 times, the presence of Hashimoto’s thyroiditis increases risk by 5.48, and an increase in BMI by one kg/m² increases risk by 1.38 times. TSH ≥7.22 uIU/L was the best-detected cut-off point, with 77.8% sensitivity and 52.9% specificity in detecting hyperprolactinemia. Conclusion: Hyperprolactinemia is prevalent in newly diagnosed SCH subjects. Thus, routine PRL estimation and consequent treatment are needed.
Keywords
Hyperprolactinemia; PRL; SCH; TSH


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