Impact of Bitter Orange(Citrus aurantium) Extract on Rats Suffering From Fatty Liver | ||
| مجلة دراسات وبحوث التربية النوعية | ||
| Volume 11, Issue 3 - Serial Number 29, July 2025, Pages 279-304 PDF (1.35 M) | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/jsezu.2025.440525 | ||
| Author | ||
| Shafika M. Sabry | ||
| Nutrition and Food Science Department, Faculty of Home Economics, Helwan University | ||
| Abstract | ||
| This research aimed to examine the beneficial effects of bitter orange extract on rat suffering from fatty liver. Thirty-six male albino rat with a weight of 160 ± 5 g were randomly allocated into six groups (6 each) . The 1st group has been fed on the basal food (-ve control). while 30 rats were fed on high-fat diet and fructose to trigger fatty livers and divided into a positive control group fed on basal diet and four treated groups with (4mg/kg, 8mg/kg, 10mg/kg, and 12mg/kg) bitter orange extract for six weeks. The outcomes illustrated that every fatty liver groups managed with bitter orange extract caused by a various diminution in FI, feed effectiveness ratio and BWG. The outcomes demonstrated a significant reduction in ALP, aspartate aminotransferase, alanine aminotransferase enzyme activity, blood urea, creatinine, and uric acid, total cholesterol, triglycerides, low-density lipoprotein and VLDL in the serum nevertheless demonstrated significant rises in values of serum high-density lipoprotein cholesterol and malondialdehyde whereas enhancing in serum glutathione for the managed groups as than the (+ve) control group. It can be recommended that the incorporating bitter orange extract into the diet due to their hypolipidemia and antioxidant properties, which offer a safer therapeutic approach against fatty liver and help mitigate its complications especially for those exposed to consume saturated fats and fructose for enhancing functions of kidney and liver. | ||
| Keywords | ||
| High fat diet - Malondialdehyde; Liver function-Lipid profile; Citrus fruits - Rats | ||
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