THE IMPACT OF BODY MASS INDEX ON CLINICOPATHOLOGICAL FEATURES AND SURVIVAL OUTCOMES IN BREAST CANCER PATIENTS: A RETROSPECTIVE COHORT STUDY. | ||||
| Egyptian Reviews for Medical and Health Sciences | ||||
| Volume 5, Issue 1, June 2025, Page 95-110 PDF (861.69 K) | ||||
| Document Type: Research Article | ||||
| DOI: 10.21608/ermhs.2025.392639.1058 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Asmaa Gharib El Hamahmi  1; Maha Lotfy Zamzam2; Eman Magdy Abd-Allah3; Fifi Mostafa El-Sayed4
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| 1Clinical oncology and nuclear medicine, Suez Canal University hospital, Ismailia, Egypt | ||||
| 2Professor of Clinical Oncology and Nuclear Medicine - Faculty of Medicine – Suez Canal University | ||||
| 3Lecturer of Clinical Oncology and Nuclear Medicine - Faculty of Medicine – Suez Canal University | ||||
| 4Assistant professor of Clinical Oncology and Nuclear Medicine - Faculty of Medicine – Suez Canal University | ||||
| Abstract | ||||
| Breast cancer remains the most common cancer among women, yet the relationship between obesity/overweight and its outcomes remains unclear. This retrospective cohort study, conducted at Suez Canal University Hospital from January 2013 to December 2018. A total of 273 breast cancer patients were included and categorized by Body Mass Index into normal weight (9.89%), overweight (21.24%), and obese (68.86%) groups, and then compared across clinico-pathological characteristics, disease-free survival, and 10-year overall survival. Results: Obese patients were generally older at diagnosis (average 50 years) and more often postmenopausal (61.7%of obese). Both obese and overweight patients presented with larger tumor sizes and more advanced tumor stages compared to normal weight individuals. Specifically, T2 tumors were prevalent in 62.1% of overweight and 68.6% of obese patients, contrasting with 33.3% in normal weight patients. Stage III disease was also higher in overweight (44.8%) and obese (27.1%) groups than in normal weight patients (22.2%). Normal weight patients showed a higher incidence of local recurrence (14.8%) and positive family history. Obesity did not appear to affect overall or disease-free survival. Conclusion: while the impact of obesity on breast cancer prognosis remains a subject of debate, this study indicates that obese and overweight breast cancer patients tend to have more aggressive disease presentations, characterized by larger tumor sizes and advanced stages. The higher local recurrence in normal weight patients might be linked to their younger age and increased incidence of triple-negative breast cancer. Further research is necessary to fully understand how obesity influences breast cancer prognosis. | ||||
| Keywords | ||||
| Breast cancer; obesity; prognosis; clinicopathologic | ||||
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