Comparative Clinical Evaluation of Photodynamic Therapy with or without Vitamin D as an Adjunctive to Non-surgical Periodontal Therapy for Management of Stage II Grade B Periodontitis: A Randomized Controlled Clinical Trial.

El Refai, Ibrahim Mahmoud; Zakaria, Mai; Helal, Marwa

doi:10.21608/edj.2025.375584.3444

	Comparative Clinical Evaluation of Photodynamic Therapy with or without Vitamin D as an Adjunctive to Non-surgical Periodontal Therapy for Management of Stage II Grade B Periodontitis: A Randomized Controlled Clinical Trial.
Egyptian Dental Journal
Volume 71, Issue 3, July 2025, Page 2155-2165 PDF (855.2 K)
Document Type: Original Article
DOI: 10.21608/edj.2025.375584.3444
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Authors
Ibrahim Mahmoud El Refai ¹; Mai Zakaria ¹; Marwa Helal ²
¹Associate Professor of Oral Diagnosis, oral Medicine and Periodontology, Faculty of Dentistry, Cairo University
²Lecturer of Oral Diagnosis, oral Medicine and Periodontology, Faculty of Dentistry, MTI University
Abstract
Aim: This study aimed to evaluate the efficacy of Photodynamic Therapy (PDT) alone versus PDT with Vitamin D adjunctive to non-surgical periodontal therapy (NSPT) in treatment stage II Grade B periodontitis. Subjects, materials and methods: A total of 24 patients (12 patients per group) with a diagnosis of Stage II Grade B periodontitis. The control group: Non- Surgical Periodontal Therapy (NSPT) + Photodynamic Therapy (PDT) alone and the test group: Non- Surgical Periodontal Therapy (SRP) + Photodynamic Therapy (PDT) with Vitamin D were performed. This randomized controlled clinical trial study examined the efficacy of PDT with or without vitamin D as an adjunctive to NSPT by comparing their effects on clinical outcomes (CAL- PI- GI) and radiographic bone loss was taken at baseline for confirming the diagnosis. NSPT was performed for the two groups. PDT was carried out using a blue halogen curing light with a wavelength of 470 nm and an intensity of 620 mW/cm2, running continuously for five minutes. Using an applicator, bottom of the periodontal pocket was treated with 2% methylene blue (the photosensitizer). After five minutes, saline was used to rinse the photosensitizer before it was subjected to a blue halogen curing light day zero. Process was repeated on days seven and twenty-one. Prior to intervention, blood samples were taken from each group to measure serum vitamin D levels. Conclusion: Considering the restrictions of this randomized controlled clinical trial study, it can be concluded that the PDT and Vitamin D supplements gave the best clinical results.
Keywords
Periodontal Disease; Periodontitis; Inflammation; Vitamin D


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