Efficacy of Asiaticoside as an Intracanal Medicament on Bacterial Load Reduction in Primary Infected Root Canals: A Randomized Clinical Trial
Alqahtani, S., Elhawary, Y., Badr, A. (2025). Efficacy of Asiaticoside as an Intracanal Medicament on Bacterial Load Reduction in Primary Infected Root Canals: A Randomized Clinical Trial. EKB Journal Management System, 71(3), 2621-2631. doi: 10.21608/edj.2025.372584.3433
Salem Abdulrahman Alqahtani; Yousry Mohammed Elhawary; Amany El-Said Badr. "Efficacy of Asiaticoside as an Intracanal Medicament on Bacterial Load Reduction in Primary Infected Root Canals: A Randomized Clinical Trial". EKB Journal Management System, 71, 3, 2025, 2621-2631. doi: 10.21608/edj.2025.372584.3433
Alqahtani, S., Elhawary, Y., Badr, A. (2025). 'Efficacy of Asiaticoside as an Intracanal Medicament on Bacterial Load Reduction in Primary Infected Root Canals: A Randomized Clinical Trial', EKB Journal Management System, 71(3), pp. 2621-2631. doi: 10.21608/edj.2025.372584.3433
Alqahtani, S., Elhawary, Y., Badr, A. Efficacy of Asiaticoside as an Intracanal Medicament on Bacterial Load Reduction in Primary Infected Root Canals: A Randomized Clinical Trial. EKB Journal Management System, 2025; 71(3): 2621-2631. doi: 10.21608/edj.2025.372584.3433

Efficacy of Asiaticoside as an Intracanal Medicament on Bacterial Load Reduction in Primary Infected Root Canals: A Randomized Clinical Trial

Egyptian Dental Journal
Volume 71, Issue 3 - Serial Number 5, July 2025, Page 2621-2631  XML PDF (1.09 MB)
Document Type: Original Article
DOI: 10.21608/edj.2025.372584.3433
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Authors
Salem Abdulrahman Alqahtani email orcid 1; Yousry Mohammed Elhawaryorcid 2; Amany El-Said Badrorcid 3
1Master student, Department of Endodontics, Faculty of Dentistry, Mansoura University, Mansoura, Egypt
2Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt
3Department of Conservative Dentistry and Endodontics, Faculty of Dentistry, Mansoura University, Mansoura, Egypt
Abstract
Abstract
Objective: This research aimed to clinically study the effectiveness of asiaticoside as intracanal medication compared to the commonly used medicaments (Ledermix and Ca(OH)2 ) in the reduction load of bacteria in necrotic teeth.
Materials and Methods: This study comprised 36 patients with single-rooted, single-canal necrotic teeth who suffered from chronic periapical periodontitis.
Before any clinical procedures, aseptic control measures were implemented. Access cavities were made, and pre-disinfection samples (S1) were obtained immediately afterward, before root canal cleaning and shaping.
The subjects were divided into three groups depending on the nature of the intracanal medicament utilized (Ca (OH)2), Ledermix, and asiaticoside. A second set of samples (S2) was collected one week after administering the intracanal medicaments. Both samples were transported in blood agar dishes for anaerobic culturing in the microbiology lab. The evolution of bacterial growth was measured as colony-forming units (CFUs) and calculated manually counting technique. The antibacterial effectiveness of intracanal medicaments was assessed by calculating the percentage reduction in bacterial colonies from S1 to S2.
Results: All evaluated intracanal medicaments showed a significant reduction in CFUs from S1 to S2 (P<0.05). Asiaticoside and Ledermix had significantly lower CFUs than Ca(OH)2 (P < 0.05), however, there was no significant difference between them (P > 0.05).
Conclusion: Asiaticoside might be considered a potential root canal medicament due to its equivalent anti-microbial impact with Ledermix and greater efficacy than Ca(OH)2 medicament.
Keywords
Asiaticoside; Ca(OH)2; Intracanal medicaments; Ledermix
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