Histopathological Evaluation of Melatonin's Role in The Treatment of Experimental Toxoplasmosis. | ||
| Zagazig University Medical Journal | ||
| Volume 31, Issue 8, August 2025, Pages 4076-4085 PDF (1.19 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2025.396463.4015 | ||
| Authors | ||
| Enas Said Elbahaie1; Naglaa Fathy Abd El-Aal2; Enas Fakhry Abdelhamed3; Ayat Mohamed Abdelrahman* 4 | ||
| 1Medical Parasitology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
| 2Medical parasitological department, Faculty of medicine, Zagazig university | ||
| 3Medical Parasitology Department,Faculty of Medicine,Zagazig University | ||
| 4Parasitological department, Faculty of medicine, Zagazig university | ||
| Abstract | ||
| Background: Toxoplasma gondii (T.gondii) is an important pathogen that can infect almost all warm-blooded animals. It has a considerable health risks, particularly in pregnant women and those with compromised immune system. Existing treatments are constrained by adverse effects. This research assessed the therapeutic efficacy of spiramycin and melatonin either individually or combined with each other. Methods: The study was performed on 55 male rats of matched age (6 weeks) and weight (200 gm) which were infected with avirulent strain of T.gondii. Rats were divided into five equal groups: (GI): Normal healthy group. (GII): Infected control group. (GIII): Infected and received spiramycin. (GIV): infected and administered melatonin. (GV): Combined spiramycin and melatonin treated group. The assessment was evaluated through parasitological and histopathological studies. Results: Our study showed that spiramycin and melatonin combination (GV) induced a highly significant decrease in the mean brain cyst counts 88.4% followed by (GIII) and (GIV) with percents 64.8% and 36.3% respectively. The treatment with melatonin by itself did not lead to a significant decrease in the parasite load, although there was a notable enhancement in the inflammatory infiltrates. Conclusion: Melatonin can be used with spiramycin as a synergistic agent in the treatment of toxoplasmosis | ||
| Keywords | ||
| Keywords: Spiramycin; Melatonin; Toxoplasmosis and Toxoplasma gondii | ||
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