Comparison of Dexmedetomidine-Nalbuphine combination Vs Dexmedetomidine alone on Clinical, Behavioral and Biochemical Investigations in Goat received TIVA via Ketofol.

Abdel-Al, Fatma Sobhy Youssry; Farghaly Ismaeel, Samy; Sabek, Ahmed; M. Abdel-Wadoud, Ibrahim; Ramadan, Mohammed Anwar; Khalil, Ahmed Hassan

doi:10.21608/bvmj.2025.378424.1942

	Comparison of Dexmedetomidine-Nalbuphine combination Vs Dexmedetomidine alone on Clinical, Behavioral and Biochemical Investigations in Goat received TIVA via Ketofol.
Benha Veterinary Medical Journal
Volume 48, Issue 2, July 2025, Page 27-35 PDF (532.57 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2025.378424.1942
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Authors
Fatma Sobhy Youssry Abdel-Al ¹; Samy Farghaly Ismaeel¹; Ahmed Sabek²; Ibrahim M. Abdel-Wadoud³; Mohammed Anwar Ramadan⁴; Ahmed Hassan Khalil¹
¹Department of Veterinary Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Kalyobiya 13736, Egypt.
²Animal Hygiene and Management Department, Faculty of Veterinary Medicine, Benha University, Egypt
³Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University,
⁴Department of Animal Internal Medicine, Faculty of Veterinary Medicine, Benha University,
Abstract
Abstract The quality of sedation and analgesia on behavioral, cardio-pulmonary and biochemical effects of a novel pre-anesthetic medication consists of dexmedetomidine -nalbuphine combination were evaluated Vs dexmedetomidine alone within bucks undergoing a TIVA using ketamine for induction and propofol for maintenance.six clinically healthy bucks were randomly assigned into two groups. The first group was subjected to intravenous injection of dexmedetomidine hydrochloride (3 mcg/kg) body weight and the second one was injected with dexmedetomidine -Nalbuphine combination (3 mcg/kg & 0.5mg/kg) body weight for dexmedetomidine and nalbuphine respectively. Anesthesia was induced by intravenous ketamine (5mg/kg) body weight and maintained through intermittent bolus of propofol (2 mg/kg) body weight. Sedative, analgesic, behavioral, cardio-pulmonary and biochemical effects of dexmedetomidine and dexmedetomidine -nalbuphine were evaluated before any treatment (s) (baseline), after premedication, after induction and at 5, 15, 30, 45, 60, 75, 90 and120 minutes after drug administration. The use of Dexmedetomidine -nalbuphine combination provide a deeper potent, rapid onset, smooth induction and recovery, prolonged sedation, anesthesia and total recovery time than bucks received dexmedetomidine alone. The behavioral parameters showed higher scores in dexmedetomidine -nalbuphine group than dexmedetomidine group. There was a significant hemodynamic and cardiovascular stability in dexmedetomidine -nalbuphine group. This study concluded that adding Nalbuphine to dexmedetomidine before total intravenous anesthesia by ketamine and propofol provide a novel anesthetic regimen that improves the quality of anesthesia and recovery with acceptable cardiopulmonary and biochemical outcomes.
Keywords
Keywords: Dexmedetomidine; Nalbuphine; Ketamine; Propofol; Goat. Total intravenous anesthesia (TIVA)


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