Myo-Inositol versus Metformin in Women with Polycystic Ovarian Syndrome Undergoing Induction of Ovulation - A Randomized Controlled Trial
Helmy, M., Shahin, A., Ali, M., Salama, H. (2025). Myo-Inositol versus Metformin in Women with Polycystic Ovarian Syndrome Undergoing Induction of Ovulation - A Randomized Controlled Trial. EKB Journal Management System, 29(4), 102-111. doi: 10.21608/egyfs.2025.441442
Medhat Essam-Eldin Helmy; Abd-Elhamid Essam Shahin; Mohamed Gamal Ali; Heba Farag Salama. "Myo-Inositol versus Metformin in Women with Polycystic Ovarian Syndrome Undergoing Induction of Ovulation - A Randomized Controlled Trial". EKB Journal Management System, 29, 4, 2025, 102-111. doi: 10.21608/egyfs.2025.441442
Helmy, M., Shahin, A., Ali, M., Salama, H. (2025). 'Myo-Inositol versus Metformin in Women with Polycystic Ovarian Syndrome Undergoing Induction of Ovulation - A Randomized Controlled Trial', EKB Journal Management System, 29(4), pp. 102-111. doi: 10.21608/egyfs.2025.441442
Helmy, M., Shahin, A., Ali, M., Salama, H. Myo-Inositol versus Metformin in Women with Polycystic Ovarian Syndrome Undergoing Induction of Ovulation - A Randomized Controlled Trial. EKB Journal Management System, 2025; 29(4): 102-111. doi: 10.21608/egyfs.2025.441442

Myo-Inositol versus Metformin in Women with Polycystic Ovarian Syndrome Undergoing Induction of Ovulation - A Randomized Controlled Trial

The Egyptian Journal of Fertility and Sterility
Volume 29, Issue 4 - Serial Number 11106352, July 2025, Page 102-111  XML PDF (274.51 K)
Document Type: Original Article
DOI: 10.21608/egyfs.2025.441442
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Authors
Medhat Essam-Eldin Helmy1; Abd-Elhamid Essam Shahin1; Mohamed Gamal Ali email 2; Heba Farag Salama3
1Professor of Obstetrics & Gynecology, Faculty of Medicine- Menoufia University
2Demonstrator of Obstetrics & Gynecology, Menoufia University Hospitals
3Assistant Professor of Obstetrics & Gynecology, Faculty of Medicine- Menouï‌a University
Abstract
Background: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disorder that affects a significant number of young women worldwide.   
Objective: to assess the effectiveness of induction of ovulation with Aromatase Inhibitors (letrozole) in women with PCOS via myoinositol versus metformin.   
Materials & Methods: In this randomized clinical tri-al, 66 women who were undergoing ovulation induction and were separated into two groups, each consisting of 33 infertile women who met the criteria of Rotterdam for PCOS. The study was carried out at Menoufia universi-ty Hospital and outpatient clinic from May 2023 to july 2024. 
Results: Demographic characteristics, cumulative preg-nancy, and ovulation rate did not exhibit any significant variances among the two groups. Fasting insulin during the follow-up was considerably lower in comparison with the baseline level in each group. The myoinositol group exhibited a significant decrease in comparison to the met-formin group.
Conclusion: we advise some PCOS patients that there is no significant difference between metformin and myoi-nositol regarding ovulation and pregnancy rates. It should also highlight that myoinositol is not inferior to met-formin.
Keywords
Metformin; Letrozole; Myoinositol; Polycys-tic ovary syndrome
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