Effect of Intraovarian Injection of Platelet-Rich Plasma on Ovarian Rejuvenation in Patients with Poor Ovarian Reserve
Solyman, A., Shaban, A., ELkholly, N., Mohammed, M., Elkholy, R. (2025). Effect of Intraovarian Injection of Platelet-Rich Plasma on Ovarian Rejuvenation in Patients with Poor Ovarian Reserve. EKB Journal Management System, 29(4), 121-131. doi: 10.21608/egyfs.2025.441445
Ayman Elsayed Solyman; Ayman Abd-Elkader Shaban; Nabih Ibrahim ELkholly; Mohammed Salah Seliem Mohammed; Reem Mohsen Elkholy. "Effect of Intraovarian Injection of Platelet-Rich Plasma on Ovarian Rejuvenation in Patients with Poor Ovarian Reserve". EKB Journal Management System, 29, 4, 2025, 121-131. doi: 10.21608/egyfs.2025.441445
Solyman, A., Shaban, A., ELkholly, N., Mohammed, M., Elkholy, R. (2025). 'Effect of Intraovarian Injection of Platelet-Rich Plasma on Ovarian Rejuvenation in Patients with Poor Ovarian Reserve', EKB Journal Management System, 29(4), pp. 121-131. doi: 10.21608/egyfs.2025.441445
Solyman, A., Shaban, A., ELkholly, N., Mohammed, M., Elkholy, R. Effect of Intraovarian Injection of Platelet-Rich Plasma on Ovarian Rejuvenation in Patients with Poor Ovarian Reserve. EKB Journal Management System, 2025; 29(4): 121-131. doi: 10.21608/egyfs.2025.441445

Effect of Intraovarian Injection of Platelet-Rich Plasma on Ovarian Rejuvenation in Patients with Poor Ovarian Reserve

The Egyptian Journal of Fertility and Sterility
Volume 29, Issue 4 - Serial Number 11106352, July 2025, Page 121-131  XML PDF (329.28 K)
Document Type: Original Article
DOI: 10.21608/egyfs.2025.441445
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Authors
Ayman Elsayed Solyman1; Ayman Abd-Elkader Shaban2; Nabih Ibrahim ELkholly2; Mohammed Salah Seliem Mohammed email 3; Reem Mohsen Elkholy4
1Assistant professor Obstetrics and gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2Professor of Obstetrics and gynecology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3Assistant lecture of Obstatric and Gynycology ,Faculty of Medicine, Menoufia University, Menoufia, Egypt
4Assistant professor of Clinical Pathology, Faculty of medicine –Menoufia University
Abstract
Background: 
Objectives: Assess the effects of intraovarian injection of autologous PRP on ovarian reserve measures and preg-nancy prognosis in women with a history of low ovarian reserve.   
Patients & Methods: At the Faculty of Medicine, Ob-stetrics and Gynecology department, the outcomes of 28 infertile patients with poor ovarian reserve was injected with autologous platelet-rich plasma (PRP) into her ova-ry, a procedure typically reserved for POR women., Ten days following the onset of menstruation, the patient un-derwent a PRP. The study Started from from May 2021 to August 2023. the study protocol was registerated by the faculty of medicine ethical scientific committee. (Ethical clearance letter number 218G/2017).   
Results: No substantial relation was noticed among preg-nancy outcome with infertility duration (P=0.792), pre-AFC (P=0.457) and post AFC (p=0.483). There was no significant relation between pre and post (FSH, LH, AMH) (P>0.05). While, pre and post estradiol were significantly decreased among women with positive pregnancy out-come (34.93±0.12, 36.67±0.58) than women with neg-ative pregnancy outcome (48.60±20.13, 49.92±19.74), (P=0.003). There was no significant relation between pre and post ovarian volume, ovarian doppler (PSV1) and (PSV2), (P>0.05). 
Conclusion: There was no substantial increase in the pregnancy rates, embryo formation, oocyte, antral folli-cle count, and Anti-Mullerian Hormone associated with intraovarian PRP injection.
Keywords
Intraovarian injection of Platelet-Rich Plas-ma; ovarian rejuvenation; poor ovarian reserve
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