New Bioactive Phytoconstituents, Antioxidant and Cytotoxic Activities of Acalypha wilkesiana Müll Arg. | ||
| Egyptian Journal of Chemistry | ||
| Articles in Press, Accepted Manuscript, Available Online from 13 July 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2025.381913.11712 | ||
| Authors | ||
| Amal Mahmoud Youssef Moustafa1; Maha Abd El-hamid El-Dmrany2; Mohamed E Mostafa* 3; Mamdouh Abdel-Mogib4 | ||
| 1Associate Professor of chemistry of natural products- Chemistry Department, Faculty of Science, Port Said University, Port Said, 42511, Egypt | ||
| 2chemistry department, faculty of science, port said, egypt | ||
| 3Plant Protection Research Institute, ARC | ||
| 4Chemisrty department, Faculty of Science, Mansoura University, Egypt | ||
| Abstract | ||
| Phytochemical investigation of Acalypha wilkesiana Müll Arg. aerial parts have resulted in isolation and structure-elucidation of two new compounds; wilkesin (1), and phosphono 2-butoxyethanimidate (2), along with the known compounds, shikimic acid (3) and luteolin-4'-O-rutinoside (4). The structures of the isolated compounds were elucidated using the spectral analyses 1D, 2D NMR, and ESI MS. In vitro antioxidant and cytotoxic potentials of A. wilkesiana ethyl acetate, and n-butanol extracts were assessed. Antioxidant activity was estimated by determining the ability to scavenge the DPPH radical, ABTS, and Nitric Oxide assays, whereas the cytotoxic effect was evaluated against breast cancer (MCF-7) cell lines using the MTT assay. A significant DPPH, ABTS and NO radical scavenging activities were recorded by n-butanol extract, demonstrating its strong capacity with IC50 values of 8.871±0.01 μg/ml for DPPH assay, 0.56 μg/ml for ABTS assay and 6.79 μg/ml for NO assay. In vitro cytotoxic findings against the MCF7 breast cancer cell line showed that ethyl acetate extract was the most potent, with IC50 value 46.78 μg/ml compared to the IC50 of doxorubicin. | ||
| Keywords | ||
| Acalypha wilkesiana; Euphorbiaceae; Wilkesin; Phosphono 2-butoxyethanimidatel; antioxidant; cytotoxicity activities | ||
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