Copper (II) Complex with Albumin Ameliorates Male Rats from Bromobenzene-Induced Renal Toxicity | ||
| Sohag Journal of Sciences | ||
| Volume 10, Issue 3, September 2025, Pages 302-306 PDF (676.62 K) | ||
| Document Type: Regular Articles | ||
| DOI: 10.21608/sjsci.2025.373403.1264 | ||
| Authors | ||
| Ismaeil M. Ali1; Nagwa M. El-Sawi1; Ahmed Y. Nassar2; Soad Shaker Ali3; Ahmed G. Khamis* 1 | ||
| 1Biochemistry Lab, Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt | ||
| 2Medical Biochemistry Department, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| 3Histology Department, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| Abstract | ||
| This study evaluates the nephroprotective effect of a copper (II)-albumin complex against bromobenzene (BB)-induced renal toxicity in male rats. BB (300 mg/kg twice weekly for 4 weeks) induced significant nephrotoxicity, evidenced by elevated serum creatinine (p< 0.01) and urea (p<0.001) versus controls. Histopathology revealed tubular necrosis and fibrosis. Co-treatment with the copper-albumin complex (400 mg/kg) reversed creatinine (p<0.05) and UA (p<0.05), demonstrating partial but significant recovery. This is the first report highlighting albumin’s dual role in enhancing copper bioavailability and renal protection. Animals (n=15/group) were divided into control, BB-only, and BB + copper-albumin groups. Serum biomarkers (urea, creatinine, and uric acid) and blinded histopathology (H&E, Sirius Red) were analyzed. The copper-albumin dose was selected based on prior efficacy studies without hepatotoxicity. Results confirm the complex’s therapeutic potential against BB-induced injury, likely via antioxidant mechanisms. The study aligns BB’s dosing with subacute toxicity models, emphasizing industrial relevance without overstating human exposure risks. In conclusion, the copper-albumin complex mitigates BB nephrotoxicity, underscoring its promise as a therapeutic agent. Further research is needed to elucidate molecular pathways and validate findings across sexes. | ||
| Keywords | ||
| Bromobenzene; nephrotoxicity; copper (II) complex with albumin; renal histology and renal functions | ||
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