Copper (II) Complex with Albumin Ameliorates Male Rats from Bromobenzene-Induced Renal Toxicity
Ali, I., El-Sawi, N., Nassar, A., Ali, S., Khamis, A. (2025). Copper (II) Complex with Albumin Ameliorates Male Rats from Bromobenzene-Induced Renal Toxicity. EKB Journal Management System, 10(3), 302-306. doi: 10.21608/sjsci.2025.373403.1264
Ismaeil M. Ali; Nagwa M. El-Sawi; Ahmed Y. Nassar; Soad Shaker Ali; Ahmed G. Khamis. "Copper (II) Complex with Albumin Ameliorates Male Rats from Bromobenzene-Induced Renal Toxicity". EKB Journal Management System, 10, 3, 2025, 302-306. doi: 10.21608/sjsci.2025.373403.1264
Ali, I., El-Sawi, N., Nassar, A., Ali, S., Khamis, A. (2025). 'Copper (II) Complex with Albumin Ameliorates Male Rats from Bromobenzene-Induced Renal Toxicity', EKB Journal Management System, 10(3), pp. 302-306. doi: 10.21608/sjsci.2025.373403.1264
Ali, I., El-Sawi, N., Nassar, A., Ali, S., Khamis, A. Copper (II) Complex with Albumin Ameliorates Male Rats from Bromobenzene-Induced Renal Toxicity. EKB Journal Management System, 2025; 10(3): 302-306. doi: 10.21608/sjsci.2025.373403.1264

Copper (II) Complex with Albumin Ameliorates Male Rats from Bromobenzene-Induced Renal Toxicity

Sohag Journal of Sciences
Volume 10, Issue 3, September 2025, Page 302-306  XML PDF (676.62 K)
Document Type: Regular Articles
DOI: 10.21608/sjsci.2025.373403.1264
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Authors
Ismaeil M. Aliorcid 1; Nagwa M. El-Sawi1; Ahmed Y. Nassar2; Soad Shaker Ali3; Ahmed G. Khamis email 1
1Biochemistry Lab, Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt
2Medical Biochemistry Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
3Histology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Abstract
This study evaluates the nephroprotective effect of a copper (II)-albumin complex against bromobenzene (BB)-induced renal toxicity in male rats. BB (300 mg/kg twice weekly for 4 weeks) induced significant nephrotoxicity, evidenced by elevated serum creatinine (p< 0.01) and urea (p<0.001) versus controls. Histopathology revealed tubular necrosis and fibrosis. Co-treatment with the copper-albumin complex (400 mg/kg) reversed creatinine (p<0.05) and UA (p<0.05), demonstrating partial but significant recovery. This is the first report highlighting albumin’s dual role in enhancing copper bioavailability and renal protection. Animals (n=15/group) were divided into control, BB-only, and BB + copper-albumin groups. Serum biomarkers (urea, creatinine, and uric acid) and blinded histopathology (H&E, Sirius Red) were analyzed. The copper-albumin dose was selected based on prior efficacy studies without hepatotoxicity. Results confirm the complex’s therapeutic potential against BB-induced injury, likely via antioxidant mechanisms. The study aligns BB’s dosing with subacute toxicity models, emphasizing industrial relevance without overstating human exposure risks. In conclusion, the copper-albumin complex mitigates BB nephrotoxicity, underscoring its promise as a therapeutic agent. Further research is needed to elucidate molecular pathways and validate findings across sexes.
Keywords
Bromobenzene; nephrotoxicity; copper (II) complex with albumin; renal histology and renal functions
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