EFFECTS OF NUTRITIONAL SUPPLEMENTS AND TESTOSTERONE HORMONE USED IN SPORT TRAINING CENTERS ON LIVERS IN MALE RATS | ||||
| Assiut Veterinary Medical Journal | ||||
| Article 11, Volume 71, Issue 186, July 2025, Page 144-153 PDF (882.44 K) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.2025.326479.1429 | ||||
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| Authors | ||||
OMAR N. SULTAN  1; MUNTAHA MAHMOUD AL-KATTAN2
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| 1Department of Biology, College of Sciences, University of Mosul, Mosul, Iraq. | ||||
| 2Department of Biology, College of Science, Mosul University, Mosul, Iraq | ||||
| Abstract | ||||
| The study aimed to evaluate the effects of some nutritional supplements (NSs) and testosterone hormone, commonly used in sports training centers, on liver function and creatine kinase (CK) enzyme activity. The experiment was conducted on 80 male white rats, divided into eight groups with 10 rats in each group. The groups included: a control group, a group of rats exercised using a treadmill, a group treated with NS, a group injected with a testosterone blend, a group dosed with NS and injected with a testosterone blend, a group treated with NS and exercised, a group injected with a testosterone blend and exercised, and a group treated with NS, injected with a testosterone blend and exercised. The results showed a significant increase in the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatine kinase (CK) enzymes in the group treated with NS and testosterone blend compared to the other groups. Histological examinations of the liver revealed severe hepatocyte necrosis, disappearance of some nuclei, apoptosis in certain cells, fatty changes (steatosis) with loss of cellular boundaries, focal infiltration of Kupffer cells, and severe sinusoidal congestion in rats treated with NS and testosterone blend. In contrast, the other groups exhibited normal hepatic cells. In conclusion, treatment with NS and testosterone blend negatively impacts liver enzyme activity and CK levels, in addition to causing pathological changes in liver tissue. | ||||
| Keywords | ||||
| Nutritional Supplement; ALT; AST; Certain Kinase; Male Rats | ||||
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