Combining Gene Expression and Candidate Gene Approach for Improvement of Growth Traits in Dromedary Camels
El-Komy, E., Amer, A., Othman, A., Ateya, A., kamal El den, M., Shehab El-Din, M., Sakr, S. (2025). Combining Gene Expression and Candidate Gene Approach for Improvement of Growth Traits in Dromedary Camels. EKB Journal Management System, (), -. doi: 10.21608/ejchem.2025.386502.11790
Esteftah Mohamed El-Komy; Ahmed Moussa Amer; Amal Abdel-Kreem Othman; Ahmed Ibrahim Ateya; mohammed atef kamal El den; Mohamed Ibrahim Shehab El-Din; Shimaa A. Sakr. "Combining Gene Expression and Candidate Gene Approach for Improvement of Growth Traits in Dromedary Camels". EKB Journal Management System, , , 2025, -. doi: 10.21608/ejchem.2025.386502.11790
El-Komy, E., Amer, A., Othman, A., Ateya, A., kamal El den, M., Shehab El-Din, M., Sakr, S. (2025). 'Combining Gene Expression and Candidate Gene Approach for Improvement of Growth Traits in Dromedary Camels', EKB Journal Management System, (), pp. -. doi: 10.21608/ejchem.2025.386502.11790
El-Komy, E., Amer, A., Othman, A., Ateya, A., kamal El den, M., Shehab El-Din, M., Sakr, S. Combining Gene Expression and Candidate Gene Approach for Improvement of Growth Traits in Dromedary Camels. EKB Journal Management System, 2025; (): -. doi: 10.21608/ejchem.2025.386502.11790

Combining Gene Expression and Candidate Gene Approach for Improvement of Growth Traits in Dromedary Camels

Egyptian Journal of Chemistry
Articles in Press, Accepted Manuscript, Available Online from 15 July 2025
Document Type: Original Article
DOI: 10.21608/ejchem.2025.386502.11790
Authors
Esteftah Mohamed El-Komy* 1; Ahmed Moussa Amer2; Amal Abdel-Kreem Othman2; Ahmed Ibrahim Ateya3; mohammed atef kamal El den4; Mohamed Ibrahim Shehab El-Din5; Shimaa A. Sakr6
1Department of Animal Production, National Research Centre, 12622, Dokki, Giza, Egypt
2Department of Camel Research, Animal Production Research Institute, Agricultural Research Center, Dokki, Giza, Egypt.
3Animal Wealth Development Department... Faculty of. Veterinary Medicine... Mansoura University
4Department of Animal Productions, Faculty of Agriculture, Al-Azhar University, Assiut, Egypt.
5Animal Production Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt
6Animal Wealth Development Department, Faculty of. Veterinary Medicine, Mansoura University
Abstract
The present research aimed to ascertain the relationship between gene expression and single nucleotide polymorphisms (SNPs) of the genes encoding glutamate decarboxylase (GAD1), fatty acid binding protein 4 (FABP4), transmembrane protein 95 (TMEM95), nucleobindin 2 (NUCB2), ATP binding cassette sub-family G member 2 (ABCG2), signal transducer and activator of transcription 5A (STAT5A), and uncoupling protein 1 (UCP1) may be related to growth traits in dromedary camels. Farm records documented the growth characteristics of 340 male dromedary camels. Following genotyping analysis, a total of 72 male dromedary camels were selected based on the availability of their phenotype records and similar conditions. Blood samples were obtained from the 72 selected individuals to perform the RNA extraction procedure. PCR-DNA sequencing of UCP1, TMEM95, NUCB2, FABP4, ABCG2, STAT5A, and GAD1 revealed SNP variations in the amplified DNA regions. These SNPs were used to classify the camels into distinct genotype groups for further analysis. A significant correlation (P < 0.01) was observed between growth traits and the detected SNPs, accompanied by notable differences in the expression profiles (UCP1, TMEM95, NUCB2, FABP4, ABCG2, STAT5A, and GAD1) among dromedary camels, which indicates their potential as surrogates for growth rates. Furthermore, dromedary camels with high growth rates may benefit from marker-assisted selection (MAS) using the identified SNPs and the studied gene expression profiles. The results may support future MAS in camels, pending further validation.
Keywords
Candidate gene; Dromedary camels; Gene expression; Growth traits
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