Role of vitamin D receptor FokI (rs10735810)variant in breast cancer susceptibility | ||||
| Mansoura Journal of Chemistry | ||||
| Volume 68, Issue 3, September 2025, Page 17-23 PDF (887.76 K) | ||||
| Document Type: Research Article | ||||
| DOI: 10.21608/mjcc.2025.375108.1003 | ||||
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| Authors | ||||
Hasnaa Hatem Khedr  1; Abdel-Aziz Fatouh Abd-Aziz2; Afaf Elsaid3; Sherif Refaat4
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| 1Biochemistry Division ,Chemistry Department , Faculty of Science, Mansoura University, Mansoura ,35516, Egypt. | ||||
| 2Biochemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt. | ||||
| 3Genetic unit, department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt. | ||||
| 4Lecturer of medical oncology, faculty of medicine, Mansoura University | ||||
| Abstract | ||||
| Abstract: Breast cancer (BC) has a significant morbidity and death rate and accounts for a disproportionate percentage of healthcare costs. It affects one of every eight women during her lifetime.BC has various genetic mutation disorders, including the VDR FokI polymorphism. The aim of this study was to evaluate the association of VDR FokI polymorphisms in Egyptian women with breast cancer. , as well as to look into the relationship between FokI polymorphisms and a variety of patient characteristics. The study included 100 women with breast cancer and 100 healthy volunteers in the control group. Genotype analysis was performed using ARMS-PCR technique. The genetic research of FokI rs10735810 revealed significant associations among BC patients and a higher percentage of co-dominant, dominant, recessive, and allelic models (p < 0.001 for all). Pathological categories (IDC and ILC) reveal a significant difference for the FokI variant (p=0.03). Otherwise, no significant correlation was detected between FokI genotype and molecular classification (p > 0.05) or tumor size (p = 0.68) in the examined instances. In conclusion, our results suggest that FokI rs10735810 polymorphism may be associated with breast cancer development in Egyptian women and could be used as a prognostic factor for breast cancer. | ||||
| Keywords | ||||
| FokI; breast cancer; genetic mutations | ||||
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