Dose Zinc Oxide Nanoparticles Potentiate the Osteogenesis of Nano-graphene Oxide, Mineral Trioxide Aggregate and Hydroxyapatite Composite | ||||
| Egyptian Journal of Veterinary Sciences | ||||
| Articles in Press, Corrected Proof, Available Online from 15 July 2025 PDF (951.44 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejvs.2025.392593.2898 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Amr Hisham Ahmed  1; Wahid Salamah Elghoul2; Ahmed Abdallah3; Samar Elsharkawy4; Samar Saeed5; Nesrine Ebrahim6; Ahmed Abdelgalil7; Ashraf Shamaa7
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| 1Surgery, anaesthesiology and radiology department faculty of veterinary medicine Cairo university | ||||
| 2Professor of surgery, Anesthesiology, and radiology department | ||||
| 3Hormones department Medical Research and clinical studies institute National Research Centre | ||||
| 4Department of Surgery, Anaesthesiology, and Radiology, Faculty of Veterinary Medicine, Cairo University. | ||||
| 5National institute of laser sciences National institute of laser sciences Cairo university | ||||
| 6Faculty of Medicine, Benha University. Benha National University, Faculty of Medicine. Benha, Egypt. Ph.D. student at Keele University, UK. | ||||
| 7Surgery, Anesthesiology, and Radiology Faculty, Veterinary Medicine Cairo university | ||||
| Abstract | ||||
| Synthetic Biodegradable composites were essential in bone tissue engineering to promote and stimulate osteogenesis and transport stem cells to the injured site. They were considered a viable substitute for natural graft materials. The current study assesses the effectiveness of nano-graphene oxide/mineral trioxide aggregate/hydroxyapatite (nGO/MTA/Hap) composite and nGO/MTA/Hap composite combined with zinc oxide nanoparticles (nZnO) in bone repair. Wistar rats were used as an animal model. A 5 mm bone defect in the right radius was created in all groups. Group (1) was assigned to receive the composite alone. whereas group (2) was treated by a composite mixed with nZnO. At 4, 8, and 12 weeks after surgery, radiographic evaluation, computed tomographic scan, hematological, and serum biochemical parameters were assessed. After four weeks, the composite groups' bone-healing process started, and it had become noticeable by eight weeks. At 12 weeks, the composite group's radiographic osteogenesis scoring was noticeably higher than that of the nZnO group. the composite group provided a higher overall modified lane score than the zinc composite group. Composite groups showed an increase in values of serum calcium, alkaline phosphatase, with a decrease in lipid peroxidase values when compared to a nZnO group. Composite only has a promising efficacy in bone healing after implantation in a critical-sized radial defect by increasing the rate and the quality of osteogenesis. Mixed nZnO in the composite decreases its efficacy in bone healing with the appearance of cytotoxic effects at the site of implantation. | ||||
| Keywords | ||||
| Nano zinc; Composite; Cytotoxic effect; Bone defect; Bone healing | ||||
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