Histopathological change in effect of Metformin Treatment on Ovarian Function in Hypothyroid Rats | ||
| Bulletin of Faculty of Science, Zagazig University | ||
| Article 10, Volume 2025, Issue 4, October 2025, Pages 105-114 PDF (2.12 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfszu.2025.337085.1447 | ||
| Authors | ||
| Samia Hussien Salam* 1; Nabil Abass Soliman2 | ||
| 1Zoology/ science/ Zagazig/ sharkia/ Egypt | ||
| 2Physiology departement Faculty of science Zagazig university Egypt | ||
| Abstract | ||
| Hypothyroidism is a common endocrine disorder in reproductive-aged women that is associated with insulin resistance and ovarian function disturbances.The aim of the present investigation was effect of metformin treatment was useful as an insulin sensitizer on TSH level, thyroid morphology in hypothyroidismand ovarian changes in PCOS. Forty adult healthy female albino rats of local strains weighingaverage150-170 gm each were divided into four equal groups. Group Ι received distilled water orally (90 days), while Group ΙΙ received distilled water orally daily in the 1st 45 days of the study, then received orally metformin (50 mg/100 g body weight) daily from the 46th day of the study till the end of the study (90th day), Group ΙII and Group IV received propylthiouracil (PTU) dissolved in distilled water (15 mg/kg body weight) orally for 45 days, Then Group ΙII received daily 1 ml distilled water orally from the 46th day of the study till the end of the study (90th day) while Group IV received metformin orally (50 mg/100 g body weight) daily from the 46th day of the study till the end of the study (90th day).Examination werethyroid and ovary histology.These results confirmed the association between thyroid hypofunction and disturbed metabolic and ovarian function,they declared that metformin treatment ameliorated ovarian and thyroid changes in rat modelsof hypothyroidism,more confirmed that metformin has anti-inflammatory and ant-oxidant activity, it improved ovarian function changes,it has no effect on ovary, observed in hypothyroidism-induced rat model. These results confirmed that metformin doesn’t affect ovarian structure in euthyroid rats. | ||
| Keywords | ||
| Metformin; propylthiouracil; hypothyroidism; ovary | ||
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