the Potential cytotoxicity and preventive effect of Ferula Assafoetida against early carcinogenic changes in colorectal cancer | ||
| Bulletin of Faculty of Science, Zagazig University | ||
| Article 14, Volume 2025, Issue 4, October 2025, Pages 144-160 PDF (1.5 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfszu.2025.359022.1482 | ||
| Authors | ||
| Aya Mohamed Abdelghany* 1; Hani Abdelsalam1; ABD EL-Aziz Abbas Diab2; Mona Abdellateif3; Wafaa Ahmed4 | ||
| 1Department physiology and Zoology . Faculty of Science, Zagazig University | ||
| 2Department physiology and Zoology . Faculty of Science, Zagazig University, Egypt. 44519, Egypt | ||
| 3Medical Biochemistry and molecular biology, Cancer Biology Department, National Cancer Institute, Cairo University | ||
| 4Medical Biochemistry and Molecular Biology, Cancer Biology Department, National Cancer Institute, Cairo University,Egypt. | ||
| Abstract | ||
| preventive and cytotoxic effect of Ferula Assafoetida against early carcinogenic changes in colorectal cancer. Methods: Trypain blue and MTT assay to measure the cytotoxicity and to evaluate the chemopreventive potential of Ferula Assafoetida on colorectal carcinoma cell line , using different Biochemical and Molecular technology . Results: The results revealed dose dependent inhibition of the viability of Caco- 2cell line, with (IC-50) 342.9 μg/mL. The Ferula Assafoetida treated cells showed significantly, increase caspase-3,8,9 expression, decreased TNF-α expression compared to control. Studies carried out by T.A, GST and MDA were chosen for investigating antioxidant effect as additional mechanism for the chemoprevention explained that a balance between free radicals and antioxidants is necessary for proper physiological function . The inhibitory effect of Ferula Assafoetida on TNF-α as target protein and elucidate its binding site. Conclusion: Ferula Assafoetida is a strong biological activity , preventive effect against cancer colon and a promising anticancer activity. Keywords : Ferula Assafoetida , chemoprevention , cytotoxicity and Molecular Bioactivity. | ||
| Keywords | ||
| Ferula Assafoetida; chemoprevention; cytotoxicity and Molecular Bioactivity | ||
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