Therapeutic Potential of Oleuropein and Taurine in Alleviating Tamoxifen-Related Kidney Injury | ||
| Bulletin of Faculty of Science, Zagazig University | ||
| Article 15, Volume 2025, Issue 4, October 2025, Pages 161-170 PDF (1.31 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfszu.2025.358468.1478 | ||
| Authors | ||
| Abdel Aziz A Diab1; Samih Ibrahim Eldahmy2; Mai Samir Abo-elfotoh Attia3; Fadwa Ayman1; Naglaa Ebrahim Abo El-enein* 4 | ||
| 1Zoology Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt | ||
| 2pharmacognosy department,faculty of pharmacy,zagazig university,zagazig,Egypt | ||
| 3Zoology department, faculty of science, Zagazig, Egypt | ||
| 4Zoology Department, Faculty of Science, Zagazig University | ||
| Abstract | ||
| ABSTRACT Background: Antioxidant and plant derived poly-phenolic are used as chemopreventive drugs to alleviate negative effects correlated with drug-induced injuries. Tamoxifen (TAM), chemotherapeutic hormonal drug, is utilized in all stage of breast cancer (BC). Nevertheless, TAM usage for a long time caused side effects such as renal toxicity. Objective: The present study aimed to investigate the effects of oleuropein (OLE) and taurine (TAU) administration on TAM induced renal dysfunction in male albino rats. Material and methods: 50 male rats were randomly divided into 5 groups (10 animals each group) as follows; group 1 [control rats], group 2; rats were received orally with TAM (20mg /kg), group 3; rats daily administrated with TAU (100mg /kg) and TAM, group 4; rats orally received with OLE (16mg/kg) and TAM and final group 5; rats daily treated with TAU and OLE in combination with TAM for 30 days. In all groups, serum urea and serum creatinine are measured. Histopathological examination of kidney tissue was done. Results: TAM rats revealed significantly increased in serum urea and creatinine. On the other hand, OLE or TAU treatment showed significantly reduced in theses parameters, but OLE and TAU together had highly improved compared with other groups and amelioration of kidney histoarchitecture. Conclusion: oleuropein and taurine combination mitigated the reverse effects of TAM induced renal damages that may be due to their potential antioxidant. | ||
| Keywords | ||
| tamoxifen; renal toxicity; taurine; antioxidant | ||
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