Ameliorative Effects of Echinacea purpurea Against Linezolid Induced Hepatotoxicity in Rats Via Apoptotic Pathway | ||||
| Egyptian Journal of Veterinary Sciences | ||||
| Articles in Press, Corrected Proof, Available Online from 15 July 2025 PDF (1.01 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejvs.2025.386205.2854 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ahmed Medhat Hegazy   1; Tamer I Abd El-Aziz2; Heba Bayoumi3; Samar S. Ibrahim4
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| 1Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University | ||||
| 2National Research centre,EGYPT | ||||
| 3Department of Histology, Faculty of Medicine, Benha University | ||||
| 4professor of forensic medicine and toxicology ,faculty of veterinary medicine ,Benha University | ||||
| Abstract | ||||
| Being an oxazolidinone antibiotic, linezolid (LZD) is widely prescribed in clinics; it works extensively by inhibiting the formation of bacterial proteins in gram-positive microorganisms. A significant therapeutic plant with a range of pharmacological qualities is Echinacea purpurea (E. purpurea). It has been discovered that E. purpurea possesses notable anti-inflammatory, antioxidant, and immunomodulatory properties. The present investigation's objective was to ascertain if E. purpurea may have hepatoprotective properties against the impact of LZD on oxidative stress, apoptotic proteins, and liver function. Twenty-eight male Wistar rats were randomly assigned to four equal groups. The groups of rats were as follows: G1 was kept under normal control conditions; G2 was orally given E. purpurea daily for continuously four weeks; G3 was administered LZD daily for 4 weeks; and G4 was given E. purpurea and LZD with the same dose and route. According to the findings, E. purpurea restores the antioxidant status as evidenced by the normalization of GSH, CAT, and MDA levels, along with the restoration of liver enzyme levels (ALT, AST, and GGT). Moreover, it significantly decreased the levels of Caspase-3 (Cas-3) and BAX as well as increase levels of BCL-2. Furthermore, E. purpurea lessens the negative effects of LZD on the liver by reducing hepatocyte congestion, degeneration, and inflammatory cellular infiltration. This is achieved through its anti-apoptotic and anti-inflammatory properties. E. purpurea may, in conclusion, aid in reducing a number of possible LZD adverse effects. | ||||
| Keywords | ||||
| Caspase-3; Echinacea purpurea; Hepatoprotection; Linezolid; Oxidative | ||||
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