Role of Serum Heat Shock Protein 70 (HSP70) in Patients with Alopecia Areata | ||
| Benha Journal of Applied Sciences | ||
| Volume 10, Issue 1, January 2025, Pages 75-78 PDF (430.41 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/bjas.2025.370676.1642 | ||
| Authors | ||
| Marwa Gamal Abd El-Sattar* 1; Ahmed M Hamed2; Ghada M Abd El-Khalek3; Amira O Abd El-Ghafar4; Radwa Mahmoud Ahmed5 | ||
| 1Dermatology, Venerology and Andrology Department, Faculty of Medicine, Benha University | ||
| 2Professor of Dermatology, Venereology and Andrology Faculty of Medicine - Benha University | ||
| 3Assistant Professor of Dermatology, Venereology and Andrology Faculty of Medicine - Benha University | ||
| 4Lecturer of Clinical and Chemical Pathology Faculty of Medicine, Benha University | ||
| 5Lecturer of Audiology, ENT Department Faculty of Medicine, Benha University | ||
| Abstract | ||
| An immune-mediated assault on hair follicles causes non-scarring hair loss in alopecia areata (AA), a common autoimmune condition. Numerous autoimmune and inflammatory diseases have been linked to heat shock protein 70 (HSP70), a molecular chaperone involved in immune regulation and cellular stress response. Recent research has also shown a possible connection between sensorineural hearing loss (SNHL) and autoimmune illnesses, maybe as a result of similar pathogenic pathways involving inflammation and immunological dysregulation. Goals: HSP70 serum levels are being investigated for their possible involvement in the etiopathogenesis of AA, their relationship to the severity of AA, and any possible connections to audiological problems in these individuals. Data Sources: Medline databases (Pub Med and Medscape) were searched and analyzed in order to find research that examined the function of HSP70 in AA that were published up to 2024. Study Selection: Every study was evaluated for inclusion on its own. If they met the following requirements, they were accepted: 1. English-language writing and publication. 2. Printed in journals with peer review. 3. Examine the involvement of HSP70 in AA. Data Extraction: Studies were eliminated if they failed to meet the requirements for inclusion. Whether ethical permission was obtained, eligibility requirements were stated, suitable controls were used, sufficient information was provided, and evaluation metrics were clearly established were all taken into consideration when evaluating the quality of the study. | ||
| Keywords | ||
| Alopecia areata; heat shock protein 70; hearing sensitivity | ||
|
Statistics Article View: 89 PDF Download: 45 |
||
